1159576-98-3
1159576-98-3
Chemical Structure
5-LOX-IN-6
- CAS No.: 1159576-98-3
- Formula:C22H18ClNO3
- Molecular Weight:379.84
IUPAC Name: ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
InChIKey: UNDGVXYIMIZWAS-UHFFFAOYSA-N
SMILES: O=C(C1=C(CC2=CC(Cl)=CC=C2)NC3=C1C=C(C4=C3C=CC=C4)O)OCC
Biological Activity: 5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research[1].
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5-LOX-IN-6 | 5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research. | |||||||||||||||||||||
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