C5a Receptor agonist, W5Cha
Based on 1 Customer Validation
C5a Receptor agonist, W5Cha (Peptide 1) is a synthetic C5a receptor hexapeptide agonist. C5a Receptor agonist, W5Cha exhibits a IC50 of 0.07 μM for binding to C5a receptor on human neutrophil membranes. C5a Receptor agonist, W5Cha activates wild-type C5a receptor and induces Ca2+ flux. C5a Receptor agonist, W5Cha can be used in studies related to neutrophil activation and inflammation.
For research use only. We do not sell to patients.
- Purity: 99.13%
- CAS No.: 144555-23-7
- Formula: C45H74N10O7
- Molecular Weight:867.13
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Biological Activity
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C5aR1 0.07 μM (IC50, human neutrophil membranes) |
C5aR1 0.04 μM (IC50, RBL-2H3 cell) |
C5aR1 0.02 μM (EC50) |
W5Cha (Peptide 1), a C5a Receptor agonist, potently competes for the C5a receptor binding sites on human neutrophil membranes, with an IC50 of 0.07 μM[1].
W5Cha, a C5a Receptor agonist, potently competes for the binding of wild-type C5a receptors on the membrane of transfected RBL-2H3 cells, with an IC50 of 0.04 μM[1].
W5Cha, a C5a Receptor agonist, competes for binding with the C5a receptor R206A mutant expressed on the membrane of transfected RBL-2H3 cells, with an IC50 of 0.06 μM, and its affinity is comparable to that of the wild-type receptor[1].
W5Cha, a C5a Receptor agonist, stimulates myeloperoxidase release from human neutrophils with an EC50 of approximately 0.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 144555-23-7
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Appearance Solid
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Molecular Weight 867.13
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Formula C45H74N10O7
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Color White to off-white
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Sequence
{N-me-Phe}-Lys-Pro-{d-Cha}-{Cha}-{d-Arg}
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Sequence Shortening
{N-me-Phe}-KP-{d-Cha}-{Cha}-{d-Arg}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (115.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1532 mL | 5.7661 mL | 11.5323 mL | 28.8307 mL |
| 5 mM | 0.2306 mL | 1.1532 mL | 2.3065 mL | 5.7661 mL | |
| 10 mM | 0.1153 mL | 0.5766 mL | 1.1532 mL | 2.8831 mL | |
| 15 mM | 0.0769 mL | 0.3844 mL | 0.7688 mL | 1.9220 mL | |
| 20 mM | 0.0577 mL | 0.2883 mL | 0.5766 mL | 1.4415 mL | |
| 25 mM | 0.0461 mL | 0.2306 mL | 0.4613 mL | 1.1532 mL | |
| 30 mM | 0.0384 mL | 0.1922 mL | 0.3844 mL | 0.9610 mL | |
| 40 mM | 0.0288 mL | 0.1442 mL | 0.2883 mL | 0.7208 mL | |
| 50 mM | 0.0231 mL | 0.1153 mL | 0.2306 mL | 0.5766 mL | |
| 60 mM | 0.0192 mL | 0.0961 mL | 0.1922 mL | 0.4805 mL | |
| 80 mM | 0.0144 mL | 0.0721 mL | 0.1442 mL | 0.3604 mL | |
| 100 mM | 0.0115 mL | 0.0577 mL | 0.1153 mL | 0.2883 mL |
C5a Receptor agonist, W5Cha Related Classifications
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