2. Anti-infection
  3. Influenza Virus
    SARS-CoV
  4. Umifenovir hydrochloride

Umifenovir hydrochloride 

Cat. No.: HY-14904A Purity: 99.31%
COA Handling Instructions

Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Umifenovir hydrochloride Chemical Structure

Umifenovir hydrochloride Chemical Structure

CAS No. : 131707-23-8

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Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 238 In-stock
Estimated Time of Arrival: December 31
100 mg USD 349 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Umifenovir hydrochloride:

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  • Biological Activity

  • Purity & Documentation

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Description

Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3].

IC50 & Target

Antiviral; Anti-influenza agent
In Vitro

Umifenovir hydrochloride exhibits a wide range and potent antiviral activity against a number of viruses including influenza A, B and C viruses, respiratory syncytial virus, adenovirus, parainfluenza type 5 and rhinovirus type 14, avian coronavirus, infectious bronchitis virus and Marek disease virus, hepatitis B virus and hepatitis C virus[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Umifenovir (45-180 mg/kg; p.o.; daily for 5 days) suppresses the transcription of influenza viruses (IFV) -associated inflammatory cytokines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice were infected with A/FM/1/47 (H1N1)[2]
Dosage: 45, 90, and 180 mg/kg
Administration: p.o.; daily for 5 days
Result: Decreased the transcription of cytokines in murine lung following the IFV A (H1N1) Infection.
Clinical Trial
Molecular Weight

513.88

Appearance

Solid

Formula

C22H26BrClN2O3S
CAS No.
SMILES

O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C(CN(C)C)=C(O)C(Br)=C3)OCC.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (48.65 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9460 mL 9.7299 mL 19.4598 mL
5 mM 0.3892 mL 1.9460 mL 3.8920 mL
10 mM 0.1946 mL 0.9730 mL 1.9460 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.86 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Umifenovir131707-23-8Influenza VirusSARS-CoVSARS coronavirusoralinflammatoryenvelopedfusionvirusInhibitorinhibitorinhibit

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