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  3. Pentosan Polysulfate Sodium

Pentosan Polysulfate Sodium 

Cat. No.: HY-A0203A
Handling Instructions

Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis.

For research use only. We do not sell to patients.

Pentosan Polysulfate Sodium Chemical Structure

Pentosan Polysulfate Sodium Chemical Structure

CAS No. : 140207-93-8

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Description

Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis[1][2][3].

IC50 & Target[2]

HIV-1

 

In Vitro

Pentosan Polysulfate Sodium has been shown to inhibit HIV-1 activity with an ED50 of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED50 of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL[2].
Pentosan Polysulfate Sodium suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production[3].

In Vivo

Pentosan Polysulfate Sodium has been shown to decreases interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan Polysulfate Sodium also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys[3].

Clinical Trial
Formula

₄₀₀₀-₆₀₀₀

CAS No.

140207-93-8

SMILES

[Pentosan Polysulfate (Sodium)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Pentosan PolysulfateHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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Pentosan Polysulfate Sodium
Cat. No.:
HY-A0203A
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