2. Inhibitory Antibodies
  3. Actoxumab

Actoxumab  (Synonyms: Anti-C. difficile Toxin A Recombinant Antibody)

Cat. No.: HY-P99277 Purity: 99.52%
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Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB.

For research use only. We do not sell to patients.

Actoxumab Chemical Structure

Actoxumab Chemical Structure

CAS No. : 1245634-25-6

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Actoxumab Related Antibodies

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Description

Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB[1].

In Vitro

Actoxumab (10 mg/kg WT or N297Q mutant (N297Q) actoxumab-bezlotoxumab; 2 h plus 24 h) significantly inhibits cell rounding activity in Vero cells under 2 ng/mL TcdA treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Actoxumab Related Antibodies
In Vivo

Actoxumab (0.1-10 mg/kg or 50 mg/kg; i.p.; single dose) shows protective effect in multiple murine models of clostridium difficile infection (CDI), including systemic and local (gut) toxin challenge models, as well as primary and recurrent models of infection in mice[1].
Actoxumab shows a synergy with Bezlotoxumab, and (combination dosage of 3, 30, 300 μg/mouse; i.p.; single dose) prevents both epithelial damage and inflammatory disease[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine C. difficile infection model in CD1 and C57BL/6 mice (6-8 weeks old)[1]
Dosage: Combination dosage of 3, 30, 300 μg/mouse; or ~0.1, 1, and 10 mg/kg
Administration: Intraperitoneal injection; single dose; 1 hour before 25 ng TcdA or 25 ng TcdB challenge
Result: Protected with Bezlotoxumab, against systemic and intestinal toxin challenge in mice.
Animal Model: Ileal loop model in CD1 and C57BL/6 mice (6-8 weeks old)[1]
Dosage: 50 mg/kg; or combined with 50 mg/kg Bezlotoxumab
Administration: Intraperitoneal injection; single dose
Result: Significantly reduced fluid accumulation in toxin-challenged mice (109.4 mg/cm).
Molecular Weight

145.9 (kDa)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Actoxumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.52%

COA (232 KB)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Actoxumab1245634-25-6Anti-C. difficile Toxin A Recombinant AntibodyOthersvgut wall damageinflammatory responseC. difficile toxin AInhibitorinhibitorinhibit

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