2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Dalazatide TFA

Dalazatide TFA  (Synonyms: ShK-186 TFA)

Cat. No.: HY-P3507A Purity: 99.17%
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Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.

For research use only. We do not sell to patients.

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Dalazatide TFA Chemical Structure

Dalazatide TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Dalazatide TFA Related Antibodies

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Description

Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease[1][2][3].

IC50 & Target

Kv1.3[1]
In Vitro

Dalazatide (ShK-186) (0-1000 pM) TFA blocks the Kv1.3 current in the Ova-specific GFP+ effector memory T (Tem) cells in a dose-dependent manner with a Kd of 65 ± 5 pM[3].
Dalazatide (0-100 nM; 3 days) TFA inhibits CCR7− T cell proliferation in a dose-dependent manner[3].
Dalazatide (100 nM; 30 min) TFA immobilizes effector memory T (Tem) cells at inflammatory sites by suppressing calcium signaling and thereby preventing β1 integrin activation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dalazatide TFA Related Antibodies

Cell Proliferation Assay[3]

Cell Line: CCR7− T cell[3]
Concentration: 0-100 nM
Incubation Time: 3 days
Result: Inhibited cell proliferation with an IC50 of 180 ± 37 pM.
In Vivo

Dalazatide (ShK-186) (100 μg/kg; s.c.; once) TFA inhibits delayed-type hypersensitivity and suppresses the in vivo motility and activation of Tem cells in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats rats, delayed-type hypersensitivity (DTH) model[3]
Dosage: 100 μg/kg
Administration: Subcutaneous injection, once
Result: Reduced DTH at all time points compared to rats given saline injections. Suppressed the proliferation of the Tem cells.
Clinical Trial
Molecular Weight

4442.08 (free acid)

Formula

C184H296N57O55PS7.xC2HF3O2
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.17%

COA (246 KB) RP-HPLC (203 KB) MS (69 KB)

Handling Instructions (2659 KB)
References
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Dalazatide TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DalazatideShK-186ShK186ShK 186Potassium ChannelKcsAmultiple sclerosis (MS)lupus erythematosuspsoriasisrheumatoid arthritistype 1 diabetesinflammatory bowel diseaseInhibitorinhibitorinhibit

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