Mulberrofuran H
Mulberrofuran H is a 2-arylbenzofuran derivative from the cultivated mulberry tree (Morus lhou (ser.) Koidz.). Mulberrofuran H demonstrates potent inhibition against substrates L-tyrosine (IC50=4.45 µM) and L-DOPA (IC50=19.70 µM). Mulberrofuran H also shows potent anti-inflammatory and antioxidative activities.
For research use only. We do not sell to patients.
- CAS No.: 89199-99-5
- Formula: C27H22O6
- Molecular Weight:442.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
4.45 µM (L-tyrosine); 19.70 µM (L-DOPA)[3]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | IC50 |
>30 μM
Compound: 5
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Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assay
Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assay
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[PMID: 19072214] |
| Hep 3B2 | IC50 |
140 nM
Compound: 5
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Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis
Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis
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[PMID: 19072214] |
| Hep 3B2 | IC50 |
15.4 μM
Compound: 5
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Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA
Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA
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[PMID: 19072214] |
| THP-1 | IC50 |
3.2 μM
Compound: 3
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Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
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[PMID: 24901948] |
Chemical Information
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CAS No. 89199-99-5
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Molecular Weight 442.46
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Formula C27H22O6
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SMILES
C[C@@]12CC(CC(C3=C(C=C(C4=CC5=C(C=C(O)C=C5)O4)C=C3O)O)=C2)C6=CC=C(O)C=C6O1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Kang J, et al. Five new diels-alder type adducts from the stem and root bark of Morus mongolica. Planta Med. 2006 Jan;72(1):52-9. [Content Brief]
[3]. Paudel P, et al. Antioxidant and anti-browning property of 2-arylbenzofuran derivatives from Morus alba Linn root bark. Food Chem. 2020 Mar 30;309:125739. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mulberrofuran H Related Classifications
HY-N3237 Related Classifications
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