Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra
- J Nat Prod. 2014 Jun 27;77(6):1297-303. doi: 10.1021/np401025f.
Affiliations
- 1. Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno , CZ-612 42 Brno, Czech Republic.
PMID: 24901948
DOI: 10.1021/np401025f
Abstract
Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated Flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.