1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Dihomo-γ-linolenic acid

Dihomo-γ-linolenic acid (Synonyms: all-cis-8,11,14-Eicosatrienoic acid)

Cat. No.: HY-A0143 Purity: >98.0%
Handling Instructions

Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.

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Dihomo-γ-linolenic acid Chemical Structure

Dihomo-γ-linolenic acid Chemical Structure

CAS No. : 1783-84-2

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Description

Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages[2].
Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727[2].
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages[2].
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation[2].
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages[2].
Dihomo-γ-linolenic acid modulates mitochondrial respiration[2].
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC[2].

Western Blot Analysis[2]

Cell Line: THP-1 macrophages
Concentration: 50 μM (pre-treated)
Incubation Time: 24 hours
Result: Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727.
In Vivo

Dihomo-γ-linolenic acid (8 mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA[3].

Animal Model: Female nude mice (48 four-week old)[3]
Dosage: 8 mg/mouse
Administration: Oral gavage, twice a week, for 35 days
Result: Suppressed metastasis potential in D5D-KD tumors.
Molecular Weight

306.48

Formula

C₂₀H₃₄O₂

CAS No.

1783-84-2

SMILES

CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

References
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Keywords:

Dihomo-γ-linolenic acidall-cis-8,11,14-Eicosatrienoic acidEndogenous Metaboliteanti-inflammatoryanti-proliferativefattyacidatherosclerosisInhibitorinhibitorinhibit

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