1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Dihomo-γ-linolenic acid

Dihomo-γ-linolenic acid (Synonyms: all-cis-8,11,14-Eicosatrienoic acid)

Cat. No.: HY-A0143 Purity: ≥98.0%
Handling Instructions

Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.

For research use only. We do not sell to patients.

Dihomo-γ-linolenic acid Chemical Structure

Dihomo-γ-linolenic acid Chemical Structure

CAS No. : 1783-84-2

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Solvent
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages[2].
Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727[2].
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages[2].
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation[2].
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages[2].
Dihomo-γ-linolenic acid modulates mitochondrial respiration[2].
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: THP-1 macrophages
Concentration: 50 μM (pre-treated)
Incubation Time: 24 hours
Result: Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727.
In Vivo

Dihomo-γ-linolenic acid (8 mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (48 four-week old)[3]
Dosage: 8 mg/mouse
Administration: Oral gavage, twice a week, for 35 days
Result: Suppressed metastasis potential in D5D-KD tumors.
Molecular Weight

306.48

Formula

C₂₀H₃₄O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (326.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2629 mL 16.3143 mL 32.6286 mL
5 mM 0.6526 mL 3.2629 mL 6.5257 mL
10 mM 0.3263 mL 1.6314 mL 3.2629 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Dihomo-γ-linolenic acid
Cat. No.:
HY-A0143
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