1. PI3K/Akt/mTOR
    Epigenetics
    TGF-beta/Smad
    NF-κB
    MAPK/ERK Pathway
    Immunology/Inflammation
  2. AMPK
    TGF-β Receptor
    NF-κB
    JNK
    AP-1
  3. IMM-H007

IMM-H007 (Synonyms: WS070117)

Cat. No.: HY-141645
Handling Instructions

IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis.

For research use only. We do not sell to patients.

IMM-H007 Chemical Structure

IMM-H007 Chemical Structure

CAS No. : 1221412-23-2

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Description

IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis[1][2][3].

In Vivo

IMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids[2].
IMM-H007 (200 mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

485.45

Formula

C22H23N5O8

CAS No.
SMILES

CC(O[[email protected]]1[[email protected]@](N2C3=NC=NC(NC4=CC(O)=CC=C4)=C3N=C2)([H])O[[email protected]@H]([[email protected]]1OC(C)=O)COC(C)=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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IMM-H007
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HY-141645
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