BET-IN-13
BET-IN-13 is a potent BET inhibitor with an IC50 value of 1.6 nM. BET-IN-13 reduces LPS-induced TNF-α, IL-1β, IL-6, and NOS2 mRNA expression levels. BET-IN-13 shows anti-inflammatory activity. BET-IN-13 has the potential for the research of acute liver injury.
For research use only. We do not sell to patients.
- CAS No.: 2506823-08-9
- Formula: C28H23N3O4S
- Molecular Weight:497.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
BRD4 BD1 57.4 nM (IC50) |
BRD4 BD2 44.4 nM (IC50) |
BRD2 BD1 79.3 nM (IC50) |
BRD2 BD2 27.5 nM (IC50) |
BRD3 BD1 45.6 nM (IC50) |
BRD3 BD2 18.9 nM (IC50) |
BRDT BD1 87.0 nM (IC50) |
BRDT BD2 43.4 nM (IC50) |
BET-IN-13 (compound 28) (1.1, 3.3, 10 µM, 2+6 h) reduces LPS (500 ng/ml) induced TNF-α, IL-1β, IL-6 and NOS2 mRNA expression levels in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:1.1, 3.3, 10 µM
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Incubation Time:Pre-treated for 2 h before stimulating with LPS for 6 h
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Result:Significantly reduced LPS (500 ng/ml) induced TNF-α, IL-1β, IL-6 and NOS2 mRNA expression levels in a dose-dependent manner.
BET-IN-13 (37.5, 75 mg/kg; i.p.; once) reduces the inflammation and hepatic damage without obvious toxicity in PS/D-GalN(d-gaiactosamine)-induced acute liver failure (ALF) mouse[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20-22g, Female C57BL/6J mice (LPS/D-GalN(d-gaiactosamine)-induced acute liver failure (ALF))[1]
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Dosage:37.5, 75 mg/kg
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Administration:I.p.; once
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Result:Reduced inflammatory responses associated with LPS/GalN-induced acute liver failure with the survival rate increased significantly to 69.2% for37.5 mg/kg and to 84.6% for 75 mg/kg.
Chemical Information
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CAS No. 2506823-08-9
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Molecular Weight 497.56
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Formula C28H23N3O4S
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SMILES
CC1=C2C(NC=C3CN(C4=C(C(N32)=C1)C=C(C=C4)CS(C)(=O)=O)C(C5=CC=C6C=CC=CC6=C5)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BET-IN-13 Related Classifications
HY-152213 Related Classifications
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