2506823-08-9
Chemical Structure
BET-IN-13
- CAS No.: 2506823-08-9
- Formula:C28H23N3O4S
- Molecular Weight:497.56
IUPAC Name: 5-(2-naphthoyl)-11-methyl-8-((methylsulfonyl)methyl)-4,5-dihydro-2,3a1,5-triazadibenzo[cd,h]azulen-1(2H)-one
InChIKey: GZEDEKFDZMUCGJ-UHFFFAOYSA-N
SMILES: CC1=C2C(NC=C3CN(C4=C(C(N32)=C1)C=C(C=C4)CS(C)(=O)=O)C(C5=CC=C6C=CC=CC6=C5)=O)=O
Biological Activity: BET-IN-13 is a potent BET inhibitor with an IC50 value of 1.6 nM. BET-IN-13 reduces LPS-induced TNF-α, IL-1β, IL-6, and NOS2 mRNA expression levels. BET-IN-13 shows anti-inflammatory activity. BET-IN-13 has the potential for the research of acute liver injury[1].
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BET-IN-13 | BET-IN-13 is a potent BET inhibitor with an IC50 value of 1.6 nM. BET-IN-13 reduces LPS-induced TNF-α, IL-1β, IL-6, and NOS2 mRNA expression levels. BET-IN-13 shows anti-inflammatory activity. BET-IN-13 has the potential for the research of acute liver injury. | |||||||||||||||||||||
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Keywords
