1. Phenols

Rosmanol 

Cat. No.: HY-N5015
Handling Instructions

Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

For research use only. We do not sell to patients.

Rosmanol Chemical Structure

Rosmanol Chemical Structure

CAS No. : 80225-53-2

Size Price Stock
5 mg USD 180 Get quote
10 mg USD 280 Get quote
25 mg USD 580 Get quote

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

In Vitro

Rosmanol exhibits the strongest inhibition on cell viability with IC50 approximately 42 μM. Rosmanol might suppress cancer cell proliferation or induce cancer cell undergoing apoptosis that lead to cell growth-inhibition. With 50 μM of Rosmanol treatment, the percentage of COLO 205 cells undergoing apoptosis increase dramatically from 9 h (29%) to 24 h (51%). Within 24 h of treatment with 50 μM Rosmanol, COLO 205 cells exhibit significant morphological changes and chromosomal condensation, which is indicative of apoptotic cell death[1]. Carnosol is a lipid protector against attack by O2[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8867 mL 14.4333 mL 28.8667 mL
5 mM 0.5773 mL 2.8867 mL 5.7733 mL
10 mM 0.2887 mL 1.4433 mL 2.8867 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

346.42

Formula

C₂₀H₂₆O₅

CAS No.

80225-53-2

SMILES

O=C1O[[email protected]]2([H])[[email protected]@H](O)C3=C(C(O)=C(O)C(C(C)C)=C3)[[email protected]@]41CCCC(C)(C)[[email protected]]24[H]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Rosmanol
Cat. No.:
HY-N5015
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Rosmanol

Cat. No.: HY-N5015