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Cat. No.: HY-155029

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sEH inhibitor-16

sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC₅₀ of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research.

For research use only. We do not sell to patients.

CAS No.: 2999636-75-6
Formula: C₃₀H₃₇N₃O
Molecular Weight:455.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

sEH inhibitor-16 Chemical Structure

CAS No.: 2999636-75-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 2 nM (sEH)^[1]

In Vivo

sEH inhibitor-16 (Compound 28) (10 mg/kg for i.p.) displays protective effects in mouse Cerulein (HY-A0190)-induced acute pancreatitis^[1].
sEH inhibitor-16 (Compound 28) (10 mg/kg for i.p.) shows an T_1/2 of 7.6 hours and a C_max of 4.17 ng/mL in CD-1 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

The murine model of AP induced by repeated Cerulein (HY-A0190) injections ^[1]
Dosage:

10mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Displayed aprotective effect evidenced bythereduction ofedema, cell infiltration, and neutrophil numbers.

Animal Model:

Male CD-1 mice (Pharmacokinetic assay)^[1]
Dosage:

10mg/kg
Administration:

Intraperitoneal injection (i.p.)

Result:

Pharmacokinetic parameters for sEH inhibitor-16 (Compound 28) in CD-1 mice^[1]

Chemical Information

CAS No. 2999636-75-6
Molecular Weight 455.63
Formula C₃₀H₃₇N₃O
SMILES

O=C(NC1=CC2=C(N(CC3=CC=C(C(C)C)C=C3)C=C2)C=C1)NCC4(C5)C[C@H](C[C@H]5C6)C[C@H]6C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Musella S, et.al. Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis. J Med Chem. 2023 Jul 13;66(13):9201-9222. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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