(R)-(-)-Ibuprofen-d3
Based on 1 Customer Validation
(R)-(-)-Ibuprofen-d3 is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 121702-86-1
- Formula: C13H15D3O2
- Molecular Weight:209.30
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 121702-86-1
-
Unlabeled Cas 51146-57-7
-
Appearance Solid
-
Molecular Weight 209.30
-
Formula C13H15D3O2
-
Color White to off-white
-
SMILES
OC([C@@H](C1=CC=C(C=C1)CC(C)C)C([2H])([2H])[2H])=O
-
Synonyms
(R)-Ibuprofen-d3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Ethanol : ≥ 60 mg/mL (286.67 mM)
DMSO : ≥ 50 mg/mL (238.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMF : ≥ 45 mg/mL (215.00 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
[3]. Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / DMSO / Ethanol | 1 mM | 4.7778 mL | 23.8892 mL | 47.7783 mL | 119.4458 mL |
| 5 mM | 0.9556 mL | 4.7778 mL | 9.5557 mL | 23.8892 mL | |
| 10 mM | 0.4778 mL | 2.3889 mL | 4.7778 mL | 11.9446 mL | |
| 15 mM | 0.3185 mL | 1.5926 mL | 3.1852 mL | 7.9631 mL | |
| 20 mM | 0.2389 mL | 1.1945 mL | 2.3889 mL | 5.9723 mL | |
| 25 mM | 0.1911 mL | 0.9556 mL | 1.9111 mL | 4.7778 mL | |
| 30 mM | 0.1593 mL | 0.7963 mL | 1.5926 mL | 3.9815 mL | |
| 40 mM | 0.1194 mL | 0.5972 mL | 1.1945 mL | 2.9861 mL | |
| 50 mM | 0.0956 mL | 0.4778 mL | 0.9556 mL | 2.3889 mL | |
| 60 mM | 0.0796 mL | 0.3982 mL | 0.7963 mL | 1.9908 mL | |
| 80 mM | 0.0597 mL | 0.2986 mL | 0.5972 mL | 1.4931 mL | |
| 100 mM | 0.0478 mL | 0.2389 mL | 0.4778 mL | 1.1945 mL |
(R)-(-)-Ibuprofen-d3 Related Classifications
HY-78131BS Related Classifications
Powered by Bioz