2. NF-κB
  3. NF-κB
  4. (R)-(-)-Ibuprofen

(R)-(-)-Ibuprofen  (Synonyms: (R)-Ibuprofen)

Cat. No.: HY-78131B Purity: 99.70% ee.: 98.82%
COA Handling Instructions

(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

For research use only. We do not sell to patients.

(R)-(-)-Ibuprofen Chemical Structure

(R)-(-)-Ibuprofen Chemical Structure

CAS No. : 51146-57-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 119 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 119 In-stock
Solid
200 mg USD 108 In-stock
500 mg   Get quote  
1 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of (R)-(-)-Ibuprofen:

(R)-(-)-Ibuprofen Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE (R)-(-)-Ibuprofen

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

IC50 & Target

NF-κB

 

In Vitro

(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids[1]. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-(-)-Ibuprofen Related Antibodies
Molecular Weight

206.28

Appearance

Solid

Formula

C13H18O2
CAS No.
SMILES

C[C@H](C1=CC=C(CC(C)C)C=C1)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (484.78 mM)

H2O : 0.67 mg/mL (3.25 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8478 mL 24.2389 mL 48.4778 mL
5 mM 0.9696 mL 4.8478 mL 9.6956 mL
10 mM 0.4848 mL 2.4239 mL 4.8478 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.70% ee.: 98.82%

COA (245 KB) HNMR (186 KB) NP-HPLC (149 KB) LCMS (113 KB)

Handling Instructions (2659 KB)
References
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(R)-(-)-Ibuprofen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(R)-(-)-Ibuprofen51146-57-7(R)-IbuprofenNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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