1. Immunology/Inflammation
  2. COX
  3. (S)-(+)-Ibuprofen

(S)-(+)-Ibuprofen (Synonyms: (S)-Ibuprofen)

Cat. No.: HY-78131A Purity: 99.98%
Handling Instructions

(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects.

For research use only. We do not sell to patients.

(S)-(+)-Ibuprofen Chemical Structure

(S)-(+)-Ibuprofen Chemical Structure

CAS No. : 51146-56-6

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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5 g USD 108 In-stock
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Description

(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects[1][2].

IC50 & Target[1]

COX-1

2.1 μM (IC50)

COX-2

1.6 μM (IC50)

In Vitro

(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 0-1000 µM; 8 days) treatment reduces concentration dependently cell survival in both cell lines to a similar extent[2].
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 0-1000 µM; 20-72 hours) treatment causes a G0/G1 phase block as well as apoptosis[2].
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 900 µM; 4-72 hours) treatment shows a down regulation of cyclin A and B and an increase of the cell cycle inhibitory protein p27Kip-1[2].
(S)-(+)-Ibuprofen inhibits COX activity, thromboxane formation, and platelet aggregation[1].
(S)-(+)-Ibuprofen inhibits the activation of NF-κB in response to T-cell stimulation with an IC50 of 61.7 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: HCT-15 and HCA-7 cells
Concentration: 0 µM, 200 µM, 400 µM, 600 µM, 700 µM, 800 µM, 900 µM, and 1000 µM
Incubation Time: 8 days
Result: Reduced concentration dependently cell survival in both cell lines to a similar extent.

Cell Cycle Analysis[2]

Cell Line: HCT-15 and HCA-7 cells
Concentration: 0 µM, 200 µM, 400 µM, 600 µM, 800 µM, 900 µM, and 1000 µM
Incubation Time: 24 hours (HCT-15) or 20 hours (HCA-7)
Result: Caused a G0/G1 phase block.

Apoptosis Analysis[2]

Cell Line: HCT-15 and HCA-7 cells
Concentration: 0 µM, 200 µM, 400 µM, 600 µM, 800 µM, 900 µM, and 1000 µM
Incubation Time: 72 hours
Result: Induced cell apoptosis.

Western Blot Analysis[2]

Cell Line: HCT-15 and HCA-7 cells
Concentration: 900 µM
Incubation Time: 4 hours, 8 hours, 16 hours, 24 hours, 32 hours, 48 hours and 72 hours
Result: Decreased levels of Cyclin D1 protein.
In Vivo

(S)-(+)-Ibuprofen (15 mg/kg/day; intraperitoneal injection; five days a week; for 4 weeks) treatment inhibits tumor growth of HCA-7 and HCT-15 xenografts in the nude mice model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI (nu/nu) male mice (6-8 week old ) injected with HCA-7 and HCT-15 cells[2]
Dosage: 15 mg/kg/day
Administration: Intraperitoneal injection; five days a week; for 4 weeks
Result: Inhibited tumor growth of HCA-7 and HCT-15 xenografts in mice.
Molecular Weight

206.28

Formula

C₁₃H₁₈O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (484.78 mM; Need ultrasonic)

Ethanol : 100 mg/mL (484.78 mM; Need ultrasonic)

H2O : 1 mg/mL (4.85 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8478 mL 24.2389 mL 48.4778 mL
5 mM 0.9696 mL 4.8478 mL 9.6956 mL
10 mM 0.4848 mL 2.4239 mL 4.8478 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.98%

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(S)-(+)-Ibuprofen
Cat. No.:
HY-78131A
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