1. Immunology/Inflammation
  2. COX
  3. (S)-(+)-Ibuprofen

(S)-(+)-Ibuprofen (Synonyms: (S)-Ibuprofen)

Cat. No.: HY-78131A Purity: 99.99% ee.: 99.13%
Handling Instructions

(S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects.

For research use only. We do not sell to patients.

(S)-(+)-Ibuprofen Chemical Structure

(S)-(+)-Ibuprofen Chemical Structure

CAS No. : 51146-56-6

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Description

(S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

IC50 & Target[1]

COX-1

2.1 μM (IC50)

COX-2

1.6 μM (IC50)

Molecular Weight

206.28

Formula

C₁₃H₁₈O₂

CAS No.

51146-56-6

SMILES

OC([[email protected]](C1=CC=C(CC(C)C)C=C1)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (484.78 mM; Need ultrasonic)

Ethanol : 100 mg/mL (484.78 mM; Need ultrasonic)

H2O : 1 mg/mL (4.85 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8478 mL 24.2389 mL 48.4778 mL
5 mM 0.9696 mL 4.8478 mL 9.6956 mL
10 mM 0.4848 mL 2.4239 mL 4.8478 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.99% ee.: 99.13%

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Keywords:

(S)-(+)-Ibuprofen(S)-IbuprofenCOXCyclooxygenaseInhibitorinhibitorinhibit

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Product name:
(S)-(+)-Ibuprofen
Cat. No.:
HY-78131A
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