Glucocorticoid receptor agonist-3 Ala-Ala-Mal

Cat. No.: HY-160178 Purity: 99.72%: FAQs
Data Sheet SDS COA Handling Instructions

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Glucocorticoid receptor agonist-3 Ala-Ala-Mal (Compound Preparation 8) is an anti-human TNFα antibody-glucocorticoid receptor agonist (GC) conjugate. Glucocorticoid receptor agonist-3 Ala-Ala-Mal can be used in the study of autoimmune and inflammatory diseases.

For research use only. We do not sell to patients.

Glucocorticoid receptor agonist-3 Ala-Ala-Mal Chemical Structure

CAS No. : 3014393-35-9

Size	Price	Stock	Quantity
1 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2150	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Glucocorticoid receptor agonist-3 Ala-Ala-Mal:

Glucocorticoid receptor agonist-4 Ala-Ala-Mal Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

910.98

Formula

C₄₉H₅₅FN₄O₁₂

CAS No.

3014393-35-9

Appearance

Solid

Color

White to off-white

SMILES

OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@@]5(C(CC4)=CC(C=C5)=O)C)([H])[C@H](C3)O)([H])C[C@@]1([H])O[C@H](C6=C(C(OCC7=CC(NC([C@H](C)NC([C@H](C)NC(CCN8C(C=CC8=O)=O)=O)=O)=O)=CC=C7)=CC=C6C)F)O2)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (109.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0977 mL	5.4886 mL	10.9772 mL
5 mM	0.2195 mL	1.0977 mL	2.1954 mL
10 mM	0.1098 mL	0.5489 mL	1.0977 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (250 KB) HNMR (175 KB) RP-HPLC (229 KB)

Handling Instructions (2659 KB)

References

[1]. Grace CHAO, et al. Human tumor necrosis factor alpha antibody glucocorticoid conjugates. Patent WO2023220549A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0977 mL	5.4886 mL	10.9772 mL	27.4430 mL
	5 mM	0.2195 mL	1.0977 mL	2.1954 mL	5.4886 mL
	10 mM	0.1098 mL	0.5489 mL	1.0977 mL	2.7443 mL
	15 mM	0.0732 mL	0.3659 mL	0.7318 mL	1.8295 mL
	20 mM	0.0549 mL	0.2744 mL	0.5489 mL	1.3721 mL
	25 mM	0.0439 mL	0.2195 mL	0.4391 mL	1.0977 mL
	30 mM	0.0366 mL	0.1830 mL	0.3659 mL	0.9148 mL
	40 mM	0.0274 mL	0.1372 mL	0.2744 mL	0.6861 mL
	50 mM	0.0220 mL	0.1098 mL	0.2195 mL	0.5489 mL
	60 mM	0.0183 mL	0.0915 mL	0.1830 mL	0.4574 mL
	80 mM	0.0137 mL	0.0686 mL	0.1372 mL	0.3430 mL
	100 mM	0.0110 mL	0.0549 mL	0.1098 mL	0.2744 mL