1. Terpenoids and Glycosides

Madecassoside (Synonyms: Asiaticoside A)

Cat. No.: HY-N0568 Purity: 99.77%
Data Sheet SDS Handling Instructions

Madecassoside is a pentacyclic triterpene isolated from Centella asitica (L.), as an anti-inflammatory, anti-oxidative activities and anti-aging agent.

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Madecassoside Chemical Structure

Madecassoside Chemical Structure

CAS No. : 34540-22-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
50 mg $150 In-stock
100 mg $240 In-stock
200 mg $390 In-stock
500 mg   Get quote  
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Description

Madecassoside is a pentacyclic triterpene isolated from Centella asitica (L.), as an anti-inflammatory, anti-oxidative activities and anti-aging agent. [1] In vitro: Madecassoside exhibit significant anti-proliferative and anti-invasive effect in HGF-induced HepG2 and SMMC-77 cells. Madecassoside inhibit the HGF-induced activation of cMET-PKC-ERK1/2-COX-2-PGE2cascade. [1] In vivo: Administration of madecassoside, p.o. , exhibit a direct anti-PF effect in mice. Madecassoside increase the expression of hepatocyte growth factor (HGF) in colon tissues, and HGF receptor antagonists attenuated its anti-PF effect. madecassoside in mice are not mediated by its metabolites or itself after absorption into blood. Instead, madecassoside increases the activity of PPAR-γ, which subsequently increases HGF expression in colonic epithelial cells. [2] The reference for administration is 12 mg/kg. [3]

References
Molecular Weight

975.12

Formula

C₄₈H₇₈O₂₀

CAS No.

34540-22-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 9.8 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Madecassoside
Cat. No.:
HY-N0568
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