2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. ThioLox

ThioLox 

Cat. No.: HY-139196 Purity: 99.97%
COA Handling Instructions

ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a Ki of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties.

For research use only. We do not sell to patients.

ThioLox Chemical Structure

ThioLox Chemical Structure

CAS No. : 1202193-89-2

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Customer Review

Based on 1 publication(s) in Google Scholar

ThioLox Related Antibodies

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5-LOX 12-LOX 15-LOX

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a Ki of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties[1].

IC50 & Target

Ki: 3.30 μM (15-LOX-1)[1]
In Vitro

ThioLox shows competitive inhibition thus indicating non-covalent interaction with the active site of the 15-LOX-1[1].
ThioLox (50 μM; 24 h) inhibits interleukin (IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS) expression in precision-cut lung slices (PCLS)[1].
ThioLox (10 μM; 16 h) prevent lipid peroxidation and mitochondrial superoxide formation in neuronal cells[1].
ThioLox (5-20 μM; 14-16 h) protects HT-22 cells against glutamate toxicity and significantly reduces neuronal cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ThioLox Related Antibodies

RT-PCR[1]

Cell Line: Precision-cut lung slices (PCLS)
Concentration: 1, 5, 10, 25 and 50 μM
Incubation Time: In combination with 10 μM linoleic acid for 20 h and stimulated with 10 ng/mL LPS for the last 4 h.
Result: Provided almost 50% inhibition of the expression of the pro-inflammatory genes IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS at 50 μM.

Cell Viability Assay[1]

Cell Line: Neuronal HT-22 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 14-16 h
Result: Significantly reduced neuronal cell death against glutamate toxicity.
In Vivo

ThioLox has a logP of 3 and shows values that comply very well with the BBB permeability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

274.38

Appearance

Solid

Formula

C15H18N2OS
CAS No.
SMILES

O=C(C1=C(N)SC(C2=CC=CC=C2)=C1)NCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (364.46 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6446 mL 18.2229 mL 36.4458 mL
5 mM 0.7289 mL 3.6446 mL 7.2892 mL
10 mM 0.3645 mL 1.8223 mL 3.6446 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (9.11 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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ThioLox Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ThioLox1202193-89-2LipoxygenaseLOXanti-inflammatoryneuroprotectiveIL-1βIL-6IL-8IL-12bTNFαiNOSHT-22Inhibitorinhibitorinhibit

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