2. Neuronal Signaling
  3. Amyloid-β
  4. Antioxidant agent-8

Antioxidant agent-8 is an orally active inhibitor of Aβ1-42 deposition. Antioxidant agent-8 inhibits fibril aggregation (IC50=11.15 µM) and promotes fibril disaggregation (IC50=6.87 µM). Antioxidant agent-8 also inhibits Cu2+-induced Aβ1-42 fibril aggregation (IC50=3.69 µM) and promotes Cu2+-induced Aβ1-42 fibril disaggregation (IC50=3.35 µM). Antioxidant agent-8 has antioxidant activity, anti-inflammatory activity, biosafety, blood-brain barrier permeability and neuroprotective effect.

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Antioxidant agent-8 Chemical Structure

Antioxidant agent-8 Chemical Structure

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Antioxidant agent-8 Related Antibodies

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Description

Antioxidant agent-8 is an orally active inhibitor of Aβ1-42 deposition. Antioxidant agent-8 inhibits fibril aggregation (IC50=11.15 µM) and promotes fibril disaggregation (IC50=6.87 µM). Antioxidant agent-8 also inhibits Cu2+-induced Aβ1-42 fibril aggregation (IC50=3.69 µM) and promotes Cu2+-induced Aβ1-42 fibril disaggregation (IC50=3.35 µM). Antioxidant agent-8 has antioxidant activity, anti-inflammatory activity, biosafety, blood-brain barrier permeability and neuroprotective effect[1].

In Vitro

Antioxidant agent-8 (compound 30) (50 µM; 24 h) selectively chelates with Cu2+, Fe2+, Zn2+, Fe3+ and Al3+ metal ions, significantly inhibits self- and Cu2+-induced Aβ1-42 fibril aggregation and disaggregation[1].
Antioxidant agent-8 (2.5, 5 and 10 µM; 24 h) promotes BV-2 cells to clear Aβ1-42, reduces Aβ1-42 induced apoptosis and protects nerves with concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antioxidant agent-8 Related Antibodies

Western Blot Analysis[1]

Cell Line: Mouse microglia BV-2 cells.
Concentration: 2.5, 5 and 10 µM.
Incubation Time: 24 h.
Result: Reduced the expression level of Aβ1-42 in cells.

Apoptosis Analysis[1]

Cell Line: Mouse microglia BV-2 cells.
Concentration: 2.5, 5 and 10 µM.
Incubation Time: 24 h.
Result: Significantly reduced Aβ1-42 induced apoptosis (cell apoptosis rate were below 30%).

Cell Viability Assay[1]

Cell Line: Mouse microglia BV-2 cells.
Concentration: 2.5, 5 and 10 µM.
Incubation Time: 24 h.
Result: Promoted cell viability and the cell survival was 75.50 % (10 µM).
In Vivo

Antioxidant agent-8 (compound 30) (15 mg/kg; i.g.; single dose) shows blood-brain barrier permeability and accumulates in the hippocampus[1].
Antioxidant agent-8 (2000 mg/kg; i.g.; single dose) exhibits biosafety[1].
Antioxidant agent-8 (20 mg/kg; p.o.; once daily for 25 d) significantly improves anxiety, memory impairment and cognitive impairment caused by Scopolamine (HY-N0296)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1].
Dosage: 15 mg/kg.
Administration: Intragastric administration; single dose.
Result: Appeared in plasma and hippocampus at 0.083, 0.167, 0.25, 0.5, 1, 2 and 4 hours after administration, and then gradually gathered in hippocampus.
Animal Model: Mice[1].
Dosage: 2000 mg/kg.
Administration: Intragastric administration; single dose.
Result: Showed insignificant toxic and side effects on heart, liver, spleen and brain.
Animal Model: SCOP-induced cognitive impairment in ICR mice (25-28 g)[1].
Dosage: 20 mg/kg.
Administration: Oral gavage; from day 7 to day 31, after 30 min of SCOP administration.
Result: Improved animal behavior, learning and memory.
Molecular Weight

248.23

Formula

C13H12O5
SMILES

O=C1CCOC(/C=C/C2=CC=C(C(O)=C2)O)=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antioxidant agent-8 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antioxidant agent-8Antioxidant agent8Antioxidant agent 8Amyloid-ββ-amyloid peptideAβAbetaBV-2 cellsMiceOrallyInhibitorinhibitorinhibit

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