1. Immunology/Inflammation
  2. COX
  3. Flunixin meglumine

Flunixin meglumine 

Cat. No.: HY-B0386 Purity: 99.65%
Handling Instructions

Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.

For research use only. We do not sell to patients.

Flunixin meglumine Chemical Structure

Flunixin meglumine Chemical Structure

CAS No. : 42461-84-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 99 In-stock
Estimated Time of Arrival: December 31
500 mg USD 90 In-stock
Estimated Time of Arrival: December 31
1 g USD 156 In-stock
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5 g USD 528 In-stock
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Description

Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. Target: COX Flunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatory and antipyretic activity. It is a potent inhibitor of the enzyme cyclooxygenase. Flunixin meglumine therapy significantly (P less than or equal to 0.05) reduced rectal temperatures and quarter signs of inflammation and improved clinically graded depression when compared with these signs in saline solution-treated controls [1]. Flunixin meglumine was selective inhibitor of COX-1. Carprofen inhibited LPS-induction of iNOS. Carprofen and, to a lesser degree, flunixin meglumine had inhibitory effects on NFκB activation [2].

IC50 & Target

COX-2

0.4 nM (IC50)

COX-1

17 nM (IC50)

Molecular Weight

491.46

Formula

C₂₁H₂₈F₃N₃O₇

CAS No.

42461-84-7

SMILES

CC1=C(C=CC=C1C(F)(F)F)NC(N=CC=C2)=C2C(O)=O.O[[email protected]]([[email protected]@H](O)CNC)[[email protected]](O)[[email protected]](O)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 44 mg/mL (89.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0348 mL 10.1738 mL 20.3475 mL
5 mM 0.4070 mL 2.0348 mL 4.0695 mL
10 mM 0.2035 mL 1.0174 mL 2.0348 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

FlunixinCOXCyclooxygenaseInhibitorinhibitorinhibit

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Flunixin meglumine
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HY-B0386
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