1. Immunology/Inflammation
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  3. Acemetacin

Acemetacin (Synonyms: TVX 1322)

Cat. No.: HY-B0482 Purity: 99.97%
Handling Instructions

Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

For research use only. We do not sell to patients.

Acemetacin Chemical Structure

Acemetacin Chemical Structure

CAS No. : 53164-05-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 84 In-stock
Estimated Time of Arrival: December 31
5 g USD 132 Get quote
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Description

Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

IC50 & Target[1]

COX-1

85 μM (IC50, in human intact cell)

In Vitro

Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. Acemetacin (TVX 1322), a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of Acemetacin (TVX 1322) is that it reduces gastric damage when compared to indometacin. From Wikipedia.

Molecular Weight

415.82

Formula

C₂₁H₁₈ClNO₆

CAS No.

53164-05-9

SMILES

O=C(OCC(O)=O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 35 mg/mL (84.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4049 mL 12.0244 mL 24.0489 mL
5 mM 0.4810 mL 2.4049 mL 4.8098 mL
10 mM 0.2405 mL 1.2024 mL 2.4049 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

AcemetacinTVX 1322TVX1322TVX-1322COXCyclooxygenaseInhibitorinhibitorinhibit

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Acemetacin
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