2. Immunology/Inflammation
  3. COX
  4. Acemetacin

Acemetacin  (Synonyms: TVX 1322)

Cat. No.: HY-B0482 Purity: 99.97%
COA Handling Instructions

Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

For research use only. We do not sell to patients.

Acemetacin Chemical Structure

Acemetacin Chemical Structure

CAS No. : 53164-05-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 55 In-stock
Solid
500 mg USD 50 In-stock
1 g USD 60 In-stock
5 g USD 132 Get quote
10 g   Get quote  
50 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

Acemetacin Related Antibodies

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Description

Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

IC50 & Target[1]

COX-1

85 μM (IC50, in human intact cell)

In Vitro

Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. Acemetacin (TVX 1322), a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of Acemetacin (TVX 1322) is that it reduces gastric damage when compared to indometacin. From Wikipedia.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Acemetacin Related Antibodies
Molecular Weight

415.82

Appearance

Solid

Formula

C21H18ClNO6
CAS No.
SMILES

O=C(OCC(O)=O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (300.61 mM; Need ultrasonic)

H2O : 1 mg/mL (2.40 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4049 mL 12.0244 mL 24.0489 mL
5 mM 0.4810 mL 2.4049 mL 4.8098 mL
10 mM 0.2405 mL 1.2024 mL 2.4049 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.00 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.97%

COA (258 KB) HNMR (172 KB) LCMS (467 KB)

Handling Instructions (2659 KB)
References
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Acemetacin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Acemetacin53164-05-9TVX 1322TVX1322TVX-1322COXCyclooxygenaseInhibitorinhibitorinhibit

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