1. Immunology/Inflammation
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  3. Acemetacin

Acemetacin (Synonyms: TVX 1322)

Cat. No.: HY-B0482 Purity: 99.97%
Handling Instructions

Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

For research use only. We do not sell to patients.

Acemetacin Chemical Structure

Acemetacin Chemical Structure

CAS No. : 53164-05-9

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
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1 g USD 84 In-stock
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5 g USD 132 In-stock
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Description

Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

IC50 & Target[1]

COX-1

85 μM (IC50, in human intact cell)

In Vitro

Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. Acemetacin (TVX 1322), a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of Acemetacin (TVX 1322) is that it reduces gastric damage when compared to indometacin. From Wikipedia.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

415.82

Formula

C₂₁H₁₈ClNO₆

CAS No.
SMILES

O=C(OCC(O)=O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (300.61 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4049 mL 12.0244 mL 24.0489 mL
5 mM 0.4810 mL 2.4049 mL 4.8098 mL
10 mM 0.2405 mL 1.2024 mL 2.4049 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.97%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

AcemetacinTVX 1322TVX1322TVX-1322COXCyclooxygenaseInhibitorinhibitorinhibit

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Acemetacin
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