Acemetacin-13C6
Acemetacin-13C6 (TVX 1322-13C6) is 13C labeled Acemetacin. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
For research use only. We do not sell to patients.
- Formula: C1513C6H14ClNO6
- Molecular Weight:417.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 53164-05-9
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Molecular Weight 417.75
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Formula C1513C6H14ClNO6
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SMILES
O=C(OCC(O)=O)CC1=C(C)N(C([13C]2=[13C][13C]=[13C](Cl)[13C]=[13C]2)=O)C3=C1C=C(OC)C=C3
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Synonyms
TVX 1322-13C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Tavares IA, et al. Non-steroidal anti-inflammatory drugs that cause relatively little gastric damage. J Gastroenterol Hepatol. 1998 Nov;13(S3):S190-S192. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)