1. Metabolic Enzyme/Protease
  2. Aminopeptidase
  3. LTA4H-IN-1

LTA4H-IN-1 

Cat. No.: HY-137298
Handling Instructions

LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders.

For research use only. We do not sell to patients.

LTA4H-IN-1 Chemical Structure

LTA4H-IN-1 Chemical Structure

CAS No. : 1799681-85-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
Estimated Time of Arrival: December 31
25 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders[1].

IC50 & Target

IC50: 2 nM (LTA4H)[1]

In Vitro

LTA4H-IN-1 (15 min) inhibits the hydrolysis of 7-amino-4-methylcoumarin (AMC) derivative of Arginine (Arg-AMC) which is catalyzed by LTA4H, with an IC50 of 2 nM[1].
LTA4H-IN-1 (30 min) inhibits LTB4 biosynthesis in a human whole blood assay (hWB), with an IC50 of 167 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LTA4H-IN-1 (0.3 mg/kg; a single p.o.) inhibits the -43% release of LTB4 compared with vehicle control in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.77

Formula

C₁₆H₁₄ClFN₆O₃

CAS No.

1799681-85-8

SMILES

O=C(O)C[[email protected]](N)CN1N=C(C2=CC=C(OC3=NC=C(Cl)C=C3F)C=C2)N=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (636.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5460 mL 12.7301 mL 25.4602 mL
5 mM 0.5092 mL 2.5460 mL 5.0920 mL
10 mM 0.2546 mL 1.2730 mL 2.5460 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

LTA4H-IN-1AminopeptidaseleukotrieneA4hydrolaseLTA4HinflammatoryautoimmuneInhibitorinhibitorinhibit

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LTA4H-IN-1
Cat. No.:
HY-137298
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