2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. NS6180

NS6180 

Cat. No.: HY-15707 Purity: 99.80%
COA Handling Instructions

NS6180 is a new orally active KCa3.1 channel inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC50value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) .

For research use only. We do not sell to patients.

NS6180 Chemical Structure

NS6180 Chemical Structure

CAS No. : 353262-04-1

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mg USD 145 In-stock
50 mg USD 541 In-stock
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NS6180 Related Antibodies

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Description

NS6180 is a new orally active KCa3.1 channel inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC50value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) [1].

In Vitro

NS6180 (0.001-1 μM) shows inhibition of human KCa3.1 with an IC50 value of 9.4 nM and a K50 value of 11 1.7 nM, respectively[1].
NS6180 (30 nM, 10 μM) has inhibition that dependent on amino acid residues T250 and V275[1].
NS6180 (1, 10, 100 and 1000 nM; 1 min) shows CCCPreported hyperpolarizations of human erythrocytes[1].
NS6180 (1, 10, 100 and 1000 nM; 1 min) blocks the erythrocyte KCa3.1 channels with IC50 values of 14 nM (human KCa3.1 channels), 15 nM (mouse) and 9 nM (rats), respectively[1]. NS6180 (0-5 μM, 48 h) suppresses rat and mouse splenocyte proliferation at submicrolar concentrations and potently inhibited IL-2 and IFN-g production, while exerting smaller effects on IL-4 and TNF-α and no effect on IL-17 production[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NS6180 Related Antibodies
In Vivo

NS6180 (i.v., i.p. and oral administration; 10 mg/kg; twice daily or once daily) has extremely low bioavailability and reduces DNBS-induced experimental colitis in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 10 mg/kg
Administration: i.v., i.p. and oral administration; 10 mg/kg; twice daily or once daily
Result: Had a plasma half-life of 3.8 h, oral or i.p. administration gave low plasma exposure (Cmax: 186 nM and 33 nM, respectively, after administration of 10 mg/kg).
Molecular Weight

323.33

Appearance

Solid

Formula

C16H12F3NOS
CAS No.
SMILES

O=C1CSC2=CC=CC=C2N1CC3=CC=CC(C(F)(F)F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (309.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0928 mL 15.4641 mL 30.9282 mL
5 mM 0.6186 mL 3.0928 mL 6.1856 mL
10 mM 0.3093 mL 1.5464 mL 3.0928 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.73 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.80%

COA (253 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References
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NS6180 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NS6180353262-04-1NS 6180NS-6180Potassium ChannelKcsAKCa3.1 channelinflammatory bowel disease (IBD)ratspharmacokineticsInhibitorinhibitorinhibit

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