1. Metabolic Enzyme/Protease
    NF-κB
    Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Gutathione S-transferase
    NF-κB
    Calcium Channel
  3. Ethacrynic acid

Ethacrynic acid 

Cat. No.: HY-B1640 Purity: 97.09%
Handling Instructions

Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.

For research use only. We do not sell to patients.

Ethacrynic acid Chemical Structure

Ethacrynic acid Chemical Structure

CAS No. : 58-54-8

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10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
50 mg USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 95 In-stock
Estimated Time of Arrival: December 31
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Description

Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

Molecular Weight

303.14

Formula

C₁₃H₁₂Cl₂O₄

CAS No.

58-54-8

SMILES

O=C(O)COC1=CC=C(C(C(CC)=C)=O)C(Cl)=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Keywords:

Ethacrynic acidGutathione S-transferaseNF-κBCalcium ChannelGlutathione transferasesGSTsNuclear factor-κBNuclear factor-kappaBCa2+ channelsCa channelsInhibitorinhibitorinhibit

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Ethacrynic acid
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