1. Metabolic Enzyme/Protease
    NF-κB
    Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Gutathione S-transferase
    NF-κB
    Calcium Channel
  3. Ethacrynic acid

Ethacrynic acid 

Cat. No.: HY-B1640 Purity: 99.98%
Handling Instructions

Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.

For research use only. We do not sell to patients.

Ethacrynic acid Chemical Structure

Ethacrynic acid Chemical Structure

CAS No. : 58-54-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
50 mg USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 95 In-stock
Estimated Time of Arrival: December 31
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Description

Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

Molecular Weight

303.14

Formula

C₁₃H₁₂Cl₂O₄

CAS No.

58-54-8

SMILES

O=C(O)COC1=CC=C(C(C(CC)=C)=O)C(Cl)=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (329.88 mM; Need ultrasonic)

H2O : 27.5 mg/mL (90.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2988 mL 16.4940 mL 32.9881 mL
5 mM 0.6598 mL 3.2988 mL 6.5976 mL
10 mM 0.3299 mL 1.6494 mL 3.2988 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.98%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

Ethacrynic acidGutathione S-transferaseNF-κBCalcium ChannelGlutathione transferasesGSTsNuclear factor-κBNuclear factor-kappaBCa2+ channelsCa channelsInhibitorinhibitorinhibit

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Ethacrynic acid
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HY-B1640
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