2. NF-κB Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Immunology/Inflammation
  3. NF-κB Glutathione S-transferase Calcium Channel NO Synthase
  4. Ethacrynic acid sodium

Ethacrynic acid sodium  (Synonyms: Etacrynic acid sodium; Sodium etacrynate)

Cat. No.: HY-B1640A
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Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.

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CAS No. : 6500-81-8

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Top Publications Citing Use of Products

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31.  [Abstract]

    Mito-ros levels measured with MitoSOX red using a flow cytometer of SH-SY5Y cells pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) for 24 h. n = 5; mean ± S.D.

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31.  [Abstract]

    Representative microscopy images of SH-SY5Y cells pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) for 24 h. Scale bar: 50 μm.

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31.  [Abstract]

    PI positive of SH-SY5Y cells pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) for 24 h. Scale bar: 50 μm.

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31.  [Abstract]

    LDH release assay of SH-SY5Y cells pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) for 24 h. Scale bar: 50 μm.

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31.  [Abstract]

    Immunoblotting analysis for GSDME cleavage and activation of SH-SY5Y cell lysates pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) treatment for 24 h. TUBB was used as loading control.

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31.  [Abstract]

    Images of mice administered with AC220 (1.5 mg/kg), Ethacrynic acid (EA, 5 mg/kg, i.p. once daily) or AC220 (1.5 mg/kg) plus EA (5 mg/kg) every day.

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31.  [Abstract]

    Ethacrynic acid (EA, 5 mg/kg, i.p. once daily). luciferase signal intensities of tumors were quantified using bioluminescence imaging.

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31.  [Abstract]

    Ethacrynic acid (EA, 5 mg/kg, i.p. once daily). Images of SH-SY5Y orthotopic tumors. Scale bar: 1 cm.

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    Description

    Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

    Molecular Weight

    325.12

    Formula

    C13H11Cl2NaO4
    CAS No.
    SMILES

    O=C(O[Na])COC1=CC=C(C(C(CC)=C)=O)C(Cl)=C1Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    Keywords:

    Ethacrynic acid6500-81-8Etacrynic acid Sodium etacrynateNF-κBGlutathione S-transferaseCalcium ChannelNO SynthaseNuclear factor-κBNuclear factor-kappaBGlutathione transferasesGSTsCa2+ channelsCa channelsNitric oxide synthasesNOSInhibitorinhibitorinhibit

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