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Ethacrynic acid sodium

(Synonyms: Etacrynic acid sodium; Sodium etacrynate)
10 Cited Publications
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Based on 10 publication(s) in Google Scholar

Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.

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  • CAS No.: 6500-81-8
  • Formula: C13H11Cl2NaO4
  • Molecular Weight:325.12
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Ethacrynic acid sodium Chemical Structure
    Ethacrynic acid sodium Chemical Structure
  • Experimental Validation Results for Ethacrynic acid sodium
  • Experimental Validation Results for Ethacrynic acid sodium
  • Experimental Validation Results for Ethacrynic acid sodium
  • Experimental Validation Results for Ethacrynic acid sodium
  • Experimental Validation Results for Ethacrynic acid sodium
  • Experimental Validation Results for Ethacrynic acid sodium
  • Experimental Validation Results for Ethacrynic acid sodium
  • Experimental Validation Results for Ethacrynic acid sodium
CAS No.: 6500-81-8
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  • Ethacrynic acid sodium Chemical Structure
    Ethacrynic acid sodium Chemical Structure
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    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31. [Abstract]

    Customer Validation
     Mito-ros levels measured with MitoSOX red using a flow cytometer of SH-SY5Y cells pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) for 24 h. n = 5; mean ± S.D.

  • 1/16

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31. [Abstract]

    Customer Validation
     Representative microscopy images of SH-SY5Y cells pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) for 24 h. Scale bar: 50 μm.

  • 1/16

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31. [Abstract]

    Customer Validation
     PI positive of SH-SY5Y cells pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) for 24 h. Scale bar: 50 μm.

  • 1/16

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31. [Abstract]

    Customer Validation
     LDH release assay of SH-SY5Y cells pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) for 24 h. Scale bar: 50 μm.

  • 1/16

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31. [Abstract]

    Customer Validation
     Immunoblotting analysis for GSDME cleavage and activation of SH-SY5Y cell lysates pretreated with 10 μM AC220 for 2 h followed by cotreatment with or without 75 μM Ethacrynic acid (EA) treatment for 24 h. TUBB was used as loading control.

  • 1/16

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31. [Abstract]

    Customer Validation
     Images of mice administered with AC220 (1.5 mg/kg), Ethacrynic acid (EA, 5 mg/kg, i.p. once daily) or AC220 (1.5 mg/kg) plus EA (5 mg/kg) every day.

  • 1/16

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31. [Abstract]

    Customer Validation
     Ethacrynic acid (EA, 5 mg/kg, i.p. once daily). luciferase signal intensities of tumors were quantified using bioluminescence imaging.

  • 1/16

    Ethacrynic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Mar 31. [Abstract]

    Customer Validation
     Ethacrynic acid (EA, 5 mg/kg, i.p. once daily). Images of SH-SY5Y orthotopic tumors. Scale bar: 1 cm.

  • Ethacrynic acid sodium