1. GPCR/G Protein
    NF-κB
  2. Glucocorticoid Receptor
    NF-κB
  3. 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 

Cat. No.: HY-136340
Handling Instructions

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization.

For research use only. We do not sell to patients.

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione Chemical Structure

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione Chemical Structure

CAS No. : 37413-91-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 100 In-stock
Estimated Time of Arrival: December 31
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Description

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1].

In Vitro

Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids[1].
VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

366.45

Formula

C₂₃H₂₆O₄

CAS No.

37413-91-5

SMILES

C[[email protected]@]12[[email protected]](CC=C2C(COC(C)=O)=O)([H])[[email protected]@]3([H])C([[email protected]@]4(C(CC3)=CC(C=C4)=O)C)=CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (272.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7289 mL 13.6444 mL 27.2889 mL
5 mM 0.5458 mL 2.7289 mL 5.4578 mL
10 mM 0.2729 mL 1.3644 mL 2.7289 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dioneGlucocorticoid ReceptorNF-κBNuclear factor-κBNuclear factor-kappaBDuchennemuscular dystrophydelta 9,11 steroidlipid peroxidationneovascularizationInhibitorinhibitorinhibit

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21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
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HY-136340
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