1. GPCR/G Protein
    Metabolic Enzyme/Protease
    NF-κB
  2. Glucocorticoid Receptor
    Mineralocorticoid Receptor
    NF-κB
  3. Vamorolone

Vamorolone (Synonyms: VBP15)

Cat. No.: HY-109017
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Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects.

For research use only. We do not sell to patients.

Vamorolone Chemical Structure

Vamorolone Chemical Structure

CAS No. : 13209-41-1

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Description

Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects[1][2].

In Vitro

Vamorolone (VBP15) inhibits TNFα-induced pro-inflammatory NF-κB signaling in C2C12 muscle cells at 1 nM or more. Vamorolone binds the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) with similar affinity[1].
Vamorolone (0.1, 1μM; 30 minutes) reduces production of IL1βand CCL5 inflammatory mediators in primary human macrophages[2].
Vamorolone is a first-in-class mineralocorticoid receptor (MR) antagonist/dissociative glucocorticoid receptor (GR) ligand[3].

In Vivo

Vamorolone (5-30 mg/kg; cherry syrup) shows a superior side effect profile compared to pharmacological glucocorticoids in mdx mice[1].
Vamorolone (30 mg/kg; orally; daily for 20 days) reduces CNS Inflammation in murine experimental autoimmune encephalomyelitis[2].

Animal Model: C57BL/6 mice (experimental autoimmune encephalomyelitis)[2]
Dosage: 30 mg/kg
Administration: Orally; daily for 20 days (starting one day prior to MOG 33-55 peptide immunization and continuing)
Result: Reduced CNS inflammation in murine experimental autoimmune encephalomyelitis.
Molecular Weight

356.46

Formula

C₂₂H₂₈O₄

CAS No.

13209-41-1

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Keywords:

VamoroloneVBP15VBP 15VBP-15Glucocorticoid ReceptorMineralocorticoid ReceptorNF-κBNuclear factor-κBNuclear factor-kappaBglucocorticoidinflammationmembranerepairDuchennemusculardystrophyfirst-in-classInhibitorinhibitorinhibit

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Vamorolone
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HY-109017
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