P-2281
Based on 1 Customer Validation
P-2281 is a mTOR inhibitor with anticancer and anti-inflammatory efficacies. P2281 inhibits mTOR activity in colon cancer cells. P-2281 suppresses Dextran sulfate sodium salt (HY-116282C) (DSS)-induced colitis by inhibiting T cell function and is efficacious in a murine model of human colitis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.81%
- No. CAS: 1112994-35-0
- Fòrmula: C9H8ClN3O
- Peso molecular:209.63
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (6 wk of age, weighing 18-22 g) by giving 3% (wt/vol) DSS in drinking water[1].
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Dosage:15 mg/kg
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Administration:ip; daily; for 10 days
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Result:Significantly inhibited DSS-induced weight loss, improved rectal bleeding index, decreased disease activity index, and reversed DSS-induced shortening of the colon.
Distinctly attenuated DSS-induced edema, prominently diminished the leukocyte infiltration in the colonic mucosa.
Blocked DSS-induced activation of mTOR.
Chemical Information
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No. CAS 1112994-35-0
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Appearance Solid
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Peso molecular 209.63
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Fòrmula C9H8ClN3O
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Color White to off-white
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SMILES
CC(C(NC1=CC=C(N=C1)C#N)=O)Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (596.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7703 mL | 23.8515 mL | 47.7031 mL | 119.2577 mL |
| 5 mM | 0.9541 mL | 4.7703 mL | 9.5406 mL | 23.8515 mL | |
| 10 mM | 0.4770 mL | 2.3852 mL | 4.7703 mL | 11.9258 mL | |
| 15 mM | 0.3180 mL | 1.5901 mL | 3.1802 mL | 7.9505 mL | |
| 20 mM | 0.2385 mL | 1.1926 mL | 2.3852 mL | 5.9629 mL | |
| 25 mM | 0.1908 mL | 0.9541 mL | 1.9081 mL | 4.7703 mL | |
| 30 mM | 0.1590 mL | 0.7951 mL | 1.5901 mL | 3.9753 mL | |
| 40 mM | 0.1193 mL | 0.5963 mL | 1.1926 mL | 2.9814 mL | |
| 50 mM | 0.0954 mL | 0.4770 mL | 0.9541 mL | 2.3852 mL | |
| 60 mM | 0.0795 mL | 0.3975 mL | 0.7951 mL | 1.9876 mL | |
| 80 mM | 0.0596 mL | 0.2981 mL | 0.5963 mL | 1.4907 mL | |
| 100 mM | 0.0477 mL | 0.2385 mL | 0.4770 mL | 1.1926 mL |
P-2281 Related Classifications
HY-118704 Related Classifications
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