1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

JNJ-7777120 

Cat. No.: HY-13508 Purity: 98.13%
Handling Instructions

JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.

For research use only. We do not sell to patients.

JNJ-7777120 Chemical Structure

JNJ-7777120 Chemical Structure

CAS No. : 459168-41-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 86 In-stock
Estimated Time of Arrival: December 31
5 mg USD 78 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors. IC50 value: 4 ±1 nM (Ki) [1] Target: histamine H4 receptor in vitro: JNJ-7777120 prevents fibronectin-induced lung fibroblast migration, thus suggesting that H4R could represent an attractive target for the development of new drugs for lung fibrosis treatment .[2] in vivo: JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. In addition, it can block the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model. [3]

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6004 mL 18.0018 mL 36.0036 mL
5 mM 0.7201 mL 3.6004 mL 7.2007 mL
10 mM 0.3600 mL 1.8002 mL 3.6004 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

277.75

Formula

C₁₄H₁₆ClN₃O

CAS No.

459168-41-3

SMILES

O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.13%

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Product Name:
JNJ-7777120
Cat. No.:
HY-13508
Quantity:

JNJ-7777120

Cat. No.: HY-13508