1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

JNJ-7777120 

Cat. No.: HY-13508 Purity: >98.0%
Data Sheet SDS Handling Instructions

JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.

For research use only. We do not sell to patients.
JNJ-7777120 Chemical Structure

JNJ-7777120 Chemical Structure

CAS No. : 459168-41-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $72 In-stock
5 mg $65 In-stock
10 mg $110 In-stock
50 mg $300 In-stock
100 mg $500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

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Description

JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors. IC50 value: 4 ±1 nM (Ki) [1] Target: histamine H4 receptor in vitro: JNJ-7777120 prevents fibronectin-induced lung fibroblast migration, thus suggesting that H4R could represent an attractive target for the development of new drugs for lung fibrosis treatment .[2] in vivo: JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. In addition, it can block the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model. [3]

References
Molecular Weight

277.75

Formula

C₁₄H₁₆ClN₃O

CAS No.

459168-41-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Product Name:
JNJ-7777120
Cat. No.:
HY-13508
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