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Cat. No.: HY-13508R

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JNJ-7777120 (Standard)

JNJ-7777120 (Standard) is the analytical standard of JNJ-7777120. This product is intended for research and analytical applications. JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory.

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 459168-41-3
Formula: C₁₄H₁₆ClN₃O
Molecular Weight:277.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JNJ-7777120 (Standard) Chemical Structure

CAS No.: 459168-41-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Bioz

Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 459168-41-3
Molecular Weight 277.75
Formula C₁₄H₁₆ClN₃O
SMILES

O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Thurmond RL, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. [Content Brief]

[2]. Ohsawa Y, et al. The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice. Allergy. 2012 Aug;67(8):1014-22. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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