Cephalotaxaceae

Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC₅₀ of 0.24 μM.

Harringtonolide is a potent RACK1 inhibitor (IC₅₀=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities.

Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity.

Salipurpin (Apigenin 5-glucoside) is a flavonoid compound isolated from the branches and leaves of Cephalotaxus fortunei, which has certain anti-inflammatory activity.

11-Hydroxycephalotaxine (Compound 1a) is a cephalotaxus alkaloid that can be isolated from Cephalotaxus species.

Dihydrocephalomannine (compound 1b), an analogue of Paclitaxel, shows reduced cytotoxicity and tubulin binding compared to Paclitaxel.

Demethylcephalotaxinone is an alkaloid. Demethylcephalotaxinone can be isolated from Hainan cycad (C. hainanensis).

(rac)-Poriol (5,7,4'-Trihydroxy-6-methylflavanone) exhibits antioxidant activity, and scavenges free radical DPPH with an IC₅₀ of 0.18 µg/mL. (rac)-Poriol inhibits the LPS (HY-D1056)-induced NO generation in RAW264.7 (98.35% inhibition rate at 10 μM), and exhibits anti-inflammatory activity. (rac)-Poriol exhibits good binding affinity with iNOS, COX-1, COX-2, TNF-α, and IL-1β.

Fortuneine is a homoerythrina alkaloid from Cephalotaxus fortunei.

Fortunolide A is a natural product.

Hainanolidol is a natural product.

Taiwanhomoflavone B is a Flavonoids product that can be isolated from the barks of Cephalotaxus fortunei.

6-Methyl-7-O-methylaromadendrin is a natural product.

4-O-Methylhelichrysetin is a Chalcones product that can be isolated from the herbs of Cephalotaxus sinensis.

3'-Methyl-4-O-methylhelichrysetin is a Chalcones product that can be isolated from the barks of Cephalotaxus sinensis.

2',6'-Dihydroxy-4,4'-dimethoxychalcone is a Chalcones product that can be isolated from the herbs of Cephalotaxus sinensis.

Wilsonine is a Alkaloids product that can be isolated from the herbs of Cephalotaxus sinensis.

Acetylcephalotaxine is a Alkaloids product that can be isolated from the barks of Cephalotaxus fortunei.

4-Hydroxycephalotaxine is a Alkaloids product that can be isolated from the barks of Cephalotaxus fortunei.