64761-48-4
Chemical Structure
Harringtonolide
- CAS No.: 64761-48-4
- Formula:C19H18O4
- Molecular Weight:310.34
IUPAC Name: (3R,4aR,10aS,11S)-5,11-dimethyl-2a,3,4a,9,10,10a1-hexahydro-1H-2,4-dioxa-3,10a-methanocyclohepta[bc]cyclopenta[jk]acenaphthylene-1,7(2a1H)-dione
InChIKey: QNJIIOHVULPMRL-PRCXHXKWSA-N
SMILES: O=C1C=C(CC2)C3=C([C@H]4C(C5O6)C3[C@@]2([C@H](C)[C@H]5O4)C6=O)C(C)=C1
Biological Activity: Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities[1].
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Harringtonolide | 98% | Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities. | ||||||||||||||||||||
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Keywords
