26833-85-2
26833-85-2
Chemical Structure
Harringtonine
- CAS No.: 26833-85-2
- Formula:C28H37NO9
- Molecular Weight:531.59
IUPAC Name: 1-((11bS,12S,14aR)-13-methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl (R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)succinate
InChIKey: HAVJATCHLFRDHY-KSZYUSJVSA-N
SMILES: O=C([C@@](CC(OC)=O)(O)CCC(C)(O)C)O[C@H]1[C@](C2=CC(OCO3)=C3C=C2CCN4CCC5)([H])[C@]45C=C1OC
Biological Activity: Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC50 of 0.24 μM.
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Harringtonine | 99.93% | Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC50 of 0.24 μM. | ||||||||||||||||||||
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Harringtonine (Standard) | ≥98% | Harringtonine (Standard) is the analytical standard of Harringtonine (HY-N0862). This product is intended for research and analytical applications. Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC50 of 0.24 μM. | ||||||||||||||||||||
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Deoxyharringtonine | Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity. | |||||||||||||||||||||
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Homoharringtonine | 99.75% | Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation. | ||||||||||||||||||||
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RdRP-IN-9 | RdRP-IN-9 (Compound 6b) is a reversible covalent allosteric inhibitor of RdRp. RdRP-IN-9 demonstrates high anti-coronavirus activity, with an EC50 value of 0.68 μM against HCoV-OC43 RdRP-IN-9 exerts a more prolonged antiviral effect by reversibly acylating Cys12 in the NiRAN domain of non-structural protein 12 (nsp 12) and exhibits synergistic anti-coronavirus activity with Molnupiravir (HY-135853) . | |||||||||||||||||||||
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Cephalotaxine | 99.21% | Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity. | ||||||||||||||||||||
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5′-Des-O-methylharringtonine | 5′-Des-O-methylharringtonine is a nature product that could be isolated from Cephalotaxus harringtonia. | |||||||||||||||||||||
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4-Hydroxycephalotaxine | 4-Hydroxycephalotaxine is a Alkaloids product that can be isolated from the barks of Cephalotaxus fortunei. | |||||||||||||||||||||
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Acetylcephalotaxine | Acetylcephalotaxine is a Alkaloids product that can be isolated from the barks of Cephalotaxus fortunei. | |||||||||||||||||||||
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Drupacine | Drupacine is a natural product, that can be isolated from Cephalotaxus harringtonia. Drupacine shows nematotoxicity and anticancer activity. | |||||||||||||||||||||
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11-Hydroxycephalotaxine | 11-Hydroxycephalotaxine (Compound 1a) is a cephalotaxus alkaloid that can be isolated from Cephalotaxus species. | |||||||||||||||||||||
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