Deoxyharringtonine
Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity.
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- CAS No.: 36804-95-2
- Formule: C28H37NO8
- Masse moléculaire:515.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
0.02 μM
Compound: Deoxyharringtonine
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Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
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10.1039/C0MD00241K |
| P388 | IC50 |
0.0075 μg/mL
Compound: 1
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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10.1021/np9604543 |
| P388 | IC50 |
0.0075 μg/mL
Compound: 5
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Antileukemic activity against P-388 leukemia cells.
Antileukemic activity against P-388 leukemia cells.
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10.1016/0960-894X(96)00302-2 |
| P388 | IC50 |
0.0075 μg/mL
Compound: deoxyharringtonine
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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10.1021/np9605044 |
In Vitro
Deoxyharringtonine acts on P388 leukemia cells with the IC50 value of 7.5 ng/mL. In addition, it has strong cytotoxic activity against hematopoietic cell lines such as HL-60, HL-60/RV+, JURKAT, ALL3, NCEB1, JEKO, MOLT-3, etc[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 36804-95-2
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Masse moléculaire 515.60
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Formule C28H37NO8
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SMILES
COC1=C[C@]23N(CCC3)CCC4=CC5=C(OCO5)C=C4[C@]2([H])[C@@H]1OC([C@@](CC(OC)=O)(O)CCC(C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Deoxyharringtonine Related Classifications
HY-133900 Related Classifications
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