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Cat. No.: HY-N7630

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Rehmapicrogenin

Name: Rehmapicrogenin
Brand: MedChemExpress
SKU: HY-N7630
Price: 270.00 USD
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6.

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CAS No.: 135447-39-1
Formule: C₁₀H₁₆O₃
Masse moléculaire:184.23

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Rehmapicrogenin Chemical Structure

CAS No.: 135447-39-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Protocole (1)
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6^[1].

IC₅₀ & Target

iNOS

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Chemical Information

CAS No. 135447-39-1
Masse moléculaire 184.23
Formule C₁₀H₁₆O₃
SMILES

O=C(C1=C(C)[C@H](O)CCC1(C)C)O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Nephrology (Carlton)

Rehmapicrogenin attenuates lipopolysaccharide-induced podocyte injury and kidney dysfunctions by regulating nuclear factor E2-related factor 2/antioxidant response element signalling. [Abstract]

2024 Aug;29(8):482-494. PMID: 38837564

Protocole

All Signal Pathway Related

Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cheuk-Lun Li, et al. Bioassay-guided isolation of anti-inflammatory components from the root of Rehmannia glutinosa and its underlying mechanism via inhibition of iNOS pathway. J Ethnopharmacol. 2012 Oct 11;143(3):867-75. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Rehmapicrogenin

1 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Protocole
Pureté et documentation
Références

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Rehmapicrogenin

Publications Citing Use of MedChemExpress (MCE) Rehmapicrogenin

Voir tous les produits spécifiques à Isoform NO Synthase

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