2. Xanthoxyletin

Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation.

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Xanthoxyletin Chemical Structure

Xanthoxyletin Chemical Structure

CAS No. : 84-99-1

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Xanthoxyletin Related Antibodies

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Description

Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation[1][2].

In Vitro

Xanthoxyletin (1-500 µM; 30 min) inhibits DPPH radical with IC50 values of 247.1 μM and 63.8 μg/mL, and also shows a ferric reducing antioxidant power (FRAP) value of 45.2 µM[2].
Xanthoxyletin (10-500 µM; 24 h) shows cytotoxicity against HepG2, HCT116 and SK-LU-1 cancer cells with IC50 values of 78.2, 79.8 and 94.4 μM, respectively[2].
Xanthoxyletin (78 and 156 μM; 12 and 24 h) induces cell apoptosis and causes low necrosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthoxyletin Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: HepG2, HCT116, SK-LU-1 and Vero cell lines
Concentration: 10-500 µM
Incubation Time: 24 hours
Result: Exhibited cytotoxicity to HepG2, HCT116 and SK-LU-1, but showed inactive effect to Vero cells.

Apoptosis Analysis[2]

Cell Line: HepG2 cell line[2]
Concentration: 78 and 156 μM
Incubation Time: 12 and 24 hours
Result: Induced apoptosis percentage of 49.6% and 64.2% at the dose of 78 and 156 μM, respectively. Showed a better apoptosis inducing effect that cisplatin.
Molecular Weight

258.27

Formula

C15H14O4
CAS No.
SMILES

O=C(O1)C=CC(C1=C2)=C(OC)C3=C2OC(C)(C)C=C3
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  • Do most proteins show cross-species activity?

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Keywords:

Xanthoxyletin84-99-1Inhibitorinhibitorinhibit

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