Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana

  • J Nat Prod. 2011 Feb 25;74(2):208-12. doi: 10.1021/np100654m.
Uraiwan Songsiang  1 ,  Tula Thongthoom ,  Chantana Boonyarat ,  Chavi Yenjai
Affiliations
  • 1. Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
PMID: 21302964 DOI: 10.1021/np100654m
Abstract

Four new Carbazole Alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known Coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with IC(50) values ranging from 1.3 to 2.7 μM. Compound 7 showed no cytotoxicity against Vero cells.