1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Sibofimloc

Sibofimloc (Synonyms: Antibiotic-202)

Cat. No.: HY-12820 Purity: 98.62%
Handling Instructions

Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD).

For research use only. We do not sell to patients.

Sibofimloc Chemical Structure

Sibofimloc Chemical Structure

CAS No. : 1616113-45-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 150 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 150 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 105 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD)[1][2].

IC50 & Target

FimH adhesion[1][2]

In Vitro

FimH is a TLR4 receptor, expressed on E. coli and other Enterobacteriaceae in host with CD. The inhibition of FimH adhesion, and consequently intracellular replication of adherent-invasive E. coli in epithelial cells, may prevent establishment of a sub-mucosal infection leading to mucosal inflammation and epithelial barrier disruption[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

649.68

Formula

C₃₅H₃₉NO₁₁

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (47.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5392 mL 7.6961 mL 15.3922 mL
5 mM 0.3078 mL 1.5392 mL 3.0784 mL
10 mM 0.1539 mL 0.7696 mL 1.5392 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Sibofimloc
Cat. No.:
HY-12820
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