2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Apoptosis
  3. RAR/RXR Apoptosis
  4. AGN194204

AGN194204  (Synonyms: IRX4204; NRX194204; VTP 194204)

Cat. No.: HY-13717
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AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions.

For research use only. We do not sell to patients.

AGN194204 Chemical Structure

AGN194204 Chemical Structure

CAS No. : 220619-73-8

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Based on 1 publication(s) in Google Scholar

AGN194204 Related Antibodies

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Description

AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions[1][2].

In Vitro

AGN194204 (NRX194204; 0-100 nM; 24 hours; E, RAW cells) treatment blocks the ability of lipopolysaccharide and tumor necrosis factor-α to induce the release of nitric oxide and interleukin 6 and the degradation of IKBα in RAW264.7 macrophage-like cells[1].
AGN194204 (NRX194204; 1 μM; 72 hours; SK-BR-3 human breast cancer cells) treatment induces apoptosis in breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AGN194204 Related Antibodies

Apoptosis Analysis[1]

Cell Line: SK-BR-3 human breast cancer cells
Concentration: 1 μM
Incubation Time: 72 hours
Result: Induced apoptosis in lung and breast cancer cells.

Western Blot Analysis[1]

Cell Line: E, RAW cells
Concentration: 0 nM, 1 nM, 10 nM and 100 nM
Incubation Time: 24 hours
Result: Blocked the ability of lipopolysaccharide and tumor necrosis factor-α to induce the release of nitric oxide and interleukin 6 and the degradation of IKBα in RAW264.7 macrophage-like cells.
In Vivo

AGN194204 (NRX194204; 30-60 mg/kg; oral administration; daily; for 15 weeks; female A/J mice) treatment significantly reduces the number and size of tumors on the surface of the lungs and reduces the total tumor volume per slide by 64% to 81% compared with the control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female A/J mice with vinyl carbamate[1]
Dosage: 30 mg/kg, 60 mg/kg
Administration: Oral administration; daily; for 15 weeks
Result: Significantly reduced the number and size of tumors on the surface of the lungs and reduced the total tumor volume per slide by 64% to 81% compared with the control group.
Clinical Trial
Molecular Weight

352.51

Formula

C24H32O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C=C(C)/C=C/[C@H]1[C@](C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)(C)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (99.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8368 mL 14.1840 mL 28.3680 mL
5 mM 0.5674 mL 2.8368 mL 5.6736 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (244 KB) Elemental Analysis Report (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8368 mL 14.1840 mL 28.3680 mL 70.9200 mL
5 mM 0.5674 mL 2.8368 mL 5.6736 mL 14.1840 mL
10 mM 0.2837 mL 1.4184 mL 2.8368 mL 7.0920 mL
15 mM 0.1891 mL 0.9456 mL 1.8912 mL 4.7280 mL
20 mM 0.1418 mL 0.7092 mL 1.4184 mL 3.5460 mL
25 mM 0.1135 mL 0.5674 mL 1.1347 mL 2.8368 mL
30 mM 0.0946 mL 0.4728 mL 0.9456 mL 2.3640 mL
40 mM 0.0709 mL 0.3546 mL 0.7092 mL 1.7730 mL
50 mM 0.0567 mL 0.2837 mL 0.5674 mL 1.4184 mL
60 mM 0.0473 mL 0.2364 mL 0.4728 mL 1.1820 mL
80 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8865 mL
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AGN194204 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGN194204220619-73-8IRX4204 NRX194204 VTP 194204AGN 194204AGN-194204IRX 4204IRX-4204NRX194204NRX 194204NRX-194204VTP194204VTP 194204VTP-194204RAR/RXRApoptosisRetinoic acid receptorsRetinoid X receptorsTNF-αlipopolysaccharideIKBαinterleukin-6anti-inflammatoryanticarcinogenicRXRαRXRβRXRγInhibitorinhibitorinhibit

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