1. MAPK/ERK Pathway
  2. Ribosomal S6 Kinase (RSK)
  3. Eudesmin

Eudesmin (Synonyms: (-)-Eudesmin; Eudesmine; (-)-Eudesmine)

Cat. No.: HY-N2357 Purity: 99.19%
Handling Instructions

Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities.

For research use only. We do not sell to patients.

Eudesmin Chemical Structure

Eudesmin Chemical Structure

CAS No. : 526-06-7

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5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities[1].

IC50 & Target

S6K1[1]

In Vitro

Treatment of mesenchymal stem cells (MSCs) with Eudesmin (20, 40, and 80μM) disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibits activation and nuclear translocation of S6K1. S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) is reduced upon Eudesmin treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

386.44

Formula

C₂₂H₂₆O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (258.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5877 mL 12.9386 mL 25.8772 mL
5 mM 0.5175 mL 2.5877 mL 5.1754 mL
10 mM 0.2588 mL 1.2939 mL 2.5877 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Eudesmin
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HY-N2357
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