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Cat. No.: HY-N2180A

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(±)-Eudesmin

Name: (±)-Eudesmin
Brand: MedChemExpress
SKU: HY-N2180A
Availability: PreOrder

(Synonyms: (±)-Eudesmine)

(±)-Eudesmin ((±)-Eudesmine) is a natural compound found in Fragaria nubicola with in vitro anti-inflammatory activity. (±)-Eudesmin inhibits NO production in LPS-activated macrophages; suppresses myeloperoxidase-dependent ROS production in zymosan-activated phagocytes; and inhibits superoxide anion production in PMA-activated macrophages. (±)-Eudesmin can be used for the research of inflammation-related diseases.

For research use only. We do not sell to patients.

CAS No.: 25305-05-9
Formula: C₂₂H₂₆O₆
Molecular Weight:386.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(±)-Eudesmin Chemical Structure

CAS No.: 25305-05-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

Description

All NO Synthase Isoforms :

In Vitro

(±)-Eudesmin (compound 4) moderately inhibits nitric oxide production in LPS-activated J774.2 mouse macrophages, with 29.3% inhibition at 25 µg/mL^[1].
(±)-Eudesmin (1-100 µg/mL; 15 min) potently inhibits myeloperoxidase-dependent ROS production in zymosan-activated human peripheral whole blood cells, with an IC₅₀ of 2.3 µg/mL^[1].
(±)-Eudesmin (0.5-25 µg/mL; 48 h) is non-cytotoxic to NIH 3T3 mouse fibroblasts, with an IC₅₀ value greater than 25 µg/mL and no toxicity observed at concentrations up to 50 µg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

NIH 3T3 mouse fibroblast cells
Concentration:

0.5, 5, 25 µg/mL
Incubation Time:

48 h
Result:

Showed no cytotoxicity toward NIH 3T3 mouse fibroblasts at concentrations up to 50 µg/mL.

Chemical Information

CAS No. 25305-05-9
Appearance Solid
Molecular Weight 386.44
Formula C₂₂H₂₆O₆
SMILES

COC1=CC(C2OCC3C(C4=CC=C(C(OC)=C4)OC)OCC23)=CC=C1OC
Synonyms

(±)-Eudesmine
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Soomro S, et al. IN-VITRO IMMUNOMODULATORY AND CYTOTOXICITY POTENTIAL OF NATURAL COMPOUNDS FROM FRAGARIA NUBICOLA. International Journal of Pharmaceutical Sciences and Research, 2020, 11(11): 5679-5684.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Purity & Documentation
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(±)-Eudesmin

All NO Synthase Isoforms