Lactucin

Cat. No.: HY-N9438: FAQs
Data Sheet Handling Instructions

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Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities.

For research use only. We do not sell to patients.

Lactucin Chemical Structure

CAS No. : 1891-29-8

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Biological Activity
Purity & Documentation
References
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Description

Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities^[1]^[2]^[3]^[4].

In Vitro

Lactucin shows moderate inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages^[1].
Lactucin (0-100 µM; 24 and 48 h) induces cytotoxic effects in HL-60 cells in a dose– and time-dependent manner^[3].
Lactucin (0-100 µM; 48 h) induces apoptosis and sub-G1 cell cycle arrest in HL-60 cells^[3].
Lactucin (10 μg/mL; 48 h) completely prevents Plasmodium falciparum parasitemia^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	HL-60
Concentration:	0, 5, 25, 50, and 100 µM
Incubation Time:	24 and 48 h
Result:	Induced significant cytotoxic effects in these cancer cells in a dose– and time-dependent manner.

Apoptosis Analysis^[3]

Cell Line:	HL-60
Concentration:	0, 5, 50 and 100 µM
Incubation Time:	48 h
Result:	Induced apoptosis. Swelling of the mitochondria and endoplasmic reticulum (ER) was detected in the cells.

Cell Cycle Analysis^[3]

Cell Line:	HL-60
Concentration:	0, 5, 50 and 100 µM
Incubation Time:	48 h
Result:	Induced sub-G1 cell cycle arrest.

In Vivo

Lactucin (15 and 30 mg/kg; i.p.; once) decreases the spontaneous locomotor activity and shows analgesic properties in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Albino-Swiss mice (18-24 g)^[2]
Dosage:	15 and 30 mg/kg
Administration:	Intraperitoneal injection, once
Result:	Decreased the spontaneous locomotor activity and showed analgesic properties in the hot plate test.

Molecular Weight

276.28

Formula

C₁₅H₁₆O₅

CAS No.

1891-29-8

SMILES

OCC([C@]1([H])[C@]2([H])[C@]([C@H](CC(C)=C13)O)([H])C(C(O2)=O)=C)=CC3=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL (904.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6195 mL	18.0976 mL	36.1952 mL
5 mM	0.7239 mL	3.6195 mL	7.2390 mL
10 mM	0.3620 mL	1.8098 mL	3.6195 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dang T, et al. Sesquiterpenoids with diverse carbon skeletons from the roots of Cichorium glandulosum and their anti-inflammatory activities. Fitoterapia. 2019 Jul;136:104170. [Content Brief]

[2]. Gromek D, et al. Biologically active preparations from Lactuca virosa L. Phytotherapy Research, 1992, 6(5): 285-287.

[3]. Zhang F H, et al. Lactucin induces potent anti-cancer effects in HL-60 human leukemia cancer cells by inducing apoptosis and sub-G1 cell cycle arrest. Bangladesh Journal of Pharmacology, 2016, 11(2): 478-484.

[4]. Bischoff TA, et al. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol. 2004 Dec;95(2-3):455-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6195 mL	18.0976 mL	36.1952 mL	90.4879 mL
	5 mM	0.7239 mL	3.6195 mL	7.2390 mL	18.0976 mL
	10 mM	0.3620 mL	1.8098 mL	3.6195 mL	9.0488 mL
	15 mM	0.2413 mL	1.2065 mL	2.4130 mL	6.0325 mL
	20 mM	0.1810 mL	0.9049 mL	1.8098 mL	4.5244 mL
	25 mM	0.1448 mL	0.7239 mL	1.4478 mL	3.6195 mL
	30 mM	0.1207 mL	0.6033 mL	1.2065 mL	3.0163 mL
	40 mM	0.0905 mL	0.4524 mL	0.9049 mL	2.2622 mL
	50 mM	0.0724 mL	0.3620 mL	0.7239 mL	1.8098 mL
	60 mM	0.0603 mL	0.3016 mL	0.6033 mL	1.5081 mL
	80 mM	0.0452 mL	0.2262 mL	0.4524 mL	1.1311 mL
	100 mM	0.0362 mL	0.1810 mL	0.3620 mL	0.9049 mL

Lactucin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lactucin1891-29-8ApoptosisParasiteLeukemiaanti-inflammatoryantimalarial activityanticancerPlasmodium falciparumanalgesic activityInhibitorinhibitorinhibit

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