Lactucin
Based on 1 Customer Validation
Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 1891-29-8
- Formula: C15H16O5
- Molecular Weight:276.28
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
More
Biological Activity
Lactucin shows moderate inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages[1].
Lactucin (0-100 µM; 24 and 48 h) induces cytotoxic effects in HL-60 cells in a dose– and time-dependent manner[3].
Lactucin (0-100 µM; 48 h) induces apoptosis and sub-G1 cell cycle arrest in HL-60 cells[3].
Lactucin (10 μg/mL; 48 h) completely prevents Plasmodium falciparum parasitemia[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60
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Concentration:0, 5, 25, 50, and 100 µM
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Incubation Time:24 and 48 h
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Result:Induced significant cytotoxic effects in these cancer cells in a dose– and time-dependent manner.
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Cell Line:HL-60
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Concentration:0, 5, 50 and 100 µM
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Incubation Time:48 h
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Result:Induced apoptosis. Swelling of the mitochondria and endoplasmic reticulum (ER) was detected in the cells.
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Cell Line:HL-60
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Concentration:0, 5, 50 and 100 µM
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Incubation Time:48 h
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Result:Induced sub-G1 cell cycle arrest.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Albino-Swiss mice (18-24 g)[2]
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Dosage:15 and 30 mg/kg
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Administration:Intraperitoneal injection, once
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Result:Decreased the spontaneous locomotor activity and showed analgesic properties in the hot plate test.
Chemical Information
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CAS No. 1891-29-8
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Appearance Solid
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Molecular Weight 276.28
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Formula C15H16O5
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Color Off-white to light yellow
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SMILES
OCC([C@]1([H])[C@]2([H])[C@]([C@H](CC(C)=C13)O)([H])C(C(O2)=O)=C)=CC3=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 150 mg/mL (542.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Dang T, et al. Sesquiterpenoids with diverse carbon skeletons from the roots of Cichorium glandulosum and their anti-inflammatory activities. Fitoterapia. 2019 Jul;136:104170. [Content Brief]
[4]. Bischoff TA, et al. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol. 2004 Dec;95(2-3):455-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6195 mL | 18.0976 mL | 36.1952 mL | 90.4879 mL |
| 5 mM | 0.7239 mL | 3.6195 mL | 7.2390 mL | 18.0976 mL | |
| 10 mM | 0.3620 mL | 1.8098 mL | 3.6195 mL | 9.0488 mL | |
| 15 mM | 0.2413 mL | 1.2065 mL | 2.4130 mL | 6.0325 mL | |
| 20 mM | 0.1810 mL | 0.9049 mL | 1.8098 mL | 4.5244 mL | |
| 25 mM | 0.1448 mL | 0.7239 mL | 1.4478 mL | 3.6195 mL | |
| 30 mM | 0.1207 mL | 0.6033 mL | 1.2065 mL | 3.0163 mL | |
| 40 mM | 0.0905 mL | 0.4524 mL | 0.9049 mL | 2.2622 mL | |
| 50 mM | 0.0724 mL | 0.3620 mL | 0.7239 mL | 1.8098 mL | |
| 60 mM | 0.0603 mL | 0.3016 mL | 0.6033 mL | 1.5081 mL | |
| 80 mM | 0.0452 mL | 0.2262 mL | 0.4524 mL | 1.1311 mL | |
| 100 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9049 mL |
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