country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-149604

Copy Link Print Information

NLRP3-IN-21

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

NLRP3-IN-21 (compound L38) is a NLRP3 inflammasome inhibitor with inflammatory properties. NLRP3-IN-21 inhibits NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly.

For research use only. We do not sell to patients.

Purity: 98.97%
CAS No.: 2956791-61-8
Formula: C₂₀H₁₃Cl₂F₃N₆O₂S
Molecular Weight:529.32

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

NLRP3-IN-21 Chemical Structure

CAS No.: 2956791-61-8

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All NOD-like Receptor (NLR) Isoforms :

Chemical Information

CAS No. 2956791-61-8
Appearance Solid
Molecular Weight 529.32
Formula C₂₀H₁₃Cl₂F₃N₆O₂S
Color White to off-white
SMILES

O=C1N(N=C(N2C1=CC3=C2C=C(S3)Cl)C(C)C)CC4=NN=C(O4)C5=CC=C(N=C5Cl)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

All

Sort by:

Journal Impact Factor

Adv Sci (Weinh)

Embryo-Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis. [Abstract]

2024 Nov;11(43):e2402299. PMID: 39316370

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (188.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8892 mL

9.4461 mL

18.8922 mL

5 mM

0.3778 mL

1.8892 mL

3.7784 mL

10 mM

0.1889 mL

0.9446 mL

1.8892 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Na Li, et al. Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis. J Med Chem. 2023 Oct 12;66(19):13428-13451. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8892 mL	9.4461 mL	18.8922 mL	47.2304 mL
	5 mM	0.3778 mL	1.8892 mL	3.7784 mL	9.4461 mL
	10 mM	0.1889 mL	0.9446 mL	1.8892 mL	4.7230 mL
	15 mM	0.1259 mL	0.6297 mL	1.2595 mL	3.1487 mL
	20 mM	0.0945 mL	0.4723 mL	0.9446 mL	2.3615 mL
	25 mM	0.0756 mL	0.3778 mL	0.7557 mL	1.8892 mL
	30 mM	0.0630 mL	0.3149 mL	0.6297 mL	1.5743 mL
	40 mM	0.0472 mL	0.2362 mL	0.4723 mL	1.1808 mL
	50 mM	0.0378 mL	0.1889 mL	0.3778 mL	0.9446 mL
	60 mM	0.0315 mL	0.1574 mL	0.3149 mL	0.7872 mL
	80 mM	0.0236 mL	0.1181 mL	0.2362 mL	0.5904 mL
	100 mM	0.0189 mL	0.0945 mL	0.1889 mL	0.4723 mL

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

NLRP3-IN-21

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Antidepressant Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Inflammasomes related Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Pattern Recognition Receptors Library

Publications Citing Use of MedChemExpress (MCE) NLRP3-IN-21

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

NLRP3-IN-21

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Antidepressant Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Inflammasomes related Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Pattern Recognition Receptors Library

Publications Citing Use of MedChemExpress (MCE) NLRP3-IN-21

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

NLRP3-IN-21 Related Classifications

HY-149604 Related Classifications