2. Epigenetics
    Stem Cell/Wnt
    Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  3. JAK
  4. Lorpucitinib

Lorpucitinib  (Synonyms: JNJ-64251330)

Cat. No.: HY-109182 Purity: 99.97%
COA Handling Instructions

Lorpucitinib is a Gut-Restricted JAK Inhibitor for the research of Inflammatory Bowel Disease.

For research use only. We do not sell to patients.

Lorpucitinib Chemical Structure

Lorpucitinib Chemical Structure

CAS No. : 2230282-02-5

Size Price Stock Quantity
5 mg USD 960 In-stock
10 mg USD 1550 In-stock
25 mg USD 3060 In-stock
50 mg USD 4900 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Lorpucitinib is a Gut-Restricted JAK Inhibitor for the research of Inflammatory Bowel Disease[1].

Clinical Trial
Molecular Weight

408.50

Appearance

Solid

Formula

C22H28N6O2
CAS No.
SMILES

O=C(NCC(C)(O)C)CC1=NC2=CN=C(NC=C3)C3=C2N1[[email protected]]4CC[[email protected]](CC#N)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (612.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4480 mL 12.2399 mL 24.4798 mL
5 mM 0.4896 mL 2.4480 mL 4.8960 mL
10 mM 0.2448 mL 1.2240 mL 2.4480 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.09 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.97%

COA (251 KB) HNMR (272 KB) LCMS (264 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Lorpucitinib2230282-02-5JNJ-64251330JNJ64251330JNJ 64251330JAKJanus kinaseInhibitorinhibitorinhibit

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