2. Others Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Reference Standards JAK STAT
  4. Lorpucitinib (Standard)

Lorpucitinib (Standard)  (Synonyms: JNJ-64251330 (Standard))

Cat. No.: HY-109182R
Handling Instructions Technical Support

Lorpucitinib (Standard) is the analytical standard of Lorpucitinib (HY-109182). This product is intended for research and analytical applications. Lorpucitinib (JNJ-64251330) is an orally active pan-JAK inhibitor. Lorpucitinib inhibits all four human JAKs, with greatest potency toward JAK1/JAK3 and JAK1/TYK2 heterodimers, and reduces STAT-3 phosphorylation downstream of JAK signaling. Lorpucitinib can be used for the research of gastrointestinal inflammatory diseases.

For research use only. We do not sell to patients.

Lorpucitinib (Standard)

Lorpucitinib (Standard) Chemical Structure

CAS No. : 2230282-02-5

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Information

Lorpucitinib (Standard) is the analytical standard of Lorpucitinib (HY-109182). This product is intended for research and analytical applications. Lorpucitinib (JNJ-64251330) is an orally active pan-JAK inhibitor. Lorpucitinib inhibits all four human JAKs, with greatest potency toward JAK1/JAK3 and JAK1/TYK2 heterodimers, and reduces STAT-3 phosphorylation downstream of JAK signaling. Lorpucitinib can be used for the research of gastrointestinal inflammatory diseases.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

408.50

Formula

C22H28N6O2
CAS No.
SMILES

O=C(NCC(C)(O)C)CC1=NC2=CN=C(NC=C3)C3=C2N1[C@H]4CC[C@H](CC#N)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Lorpucitinib (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lorpucitinib (Standard)2230282-02-5JNJ-64251330 (Standard)Reference StandardsJAKSTATJanus kinasehuman peripheral blood mononuclear cellsSTAT-3JAK1TYK2JAK3Inhibitorinhibitorinhibit

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