Anti-inflammatory agent 33
Anti-inflammatory agent 33 is a potent p38α inhibitor. Anti-inflammatory agent 33 inhibits NO production. Anti-inflammatory agent 33 inhibits LPS-induced iNOS, COX-2, p-p38α, p-MK2 protein expression. Anti-inflammatory agent 33 shows anti-inflammatory activity.
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- CAS No.: 2816993-09-4
- Formule: C22H15N3O5S
- Masse moléculaire:433.44
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
1.25 μM
Compound: 8j
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by griess reagent based assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by griess reagent based assay
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[PMID: 36450214] |
| RAW264.7 | IC50 |
11.53 μM
Compound: 8j
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by ELISA analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by ELISA analysis
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[PMID: 36450214] |
| RAW264.7 | IC50 |
8.48 μM
Compound: 8j
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-1beta production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by ELISA analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-1beta production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by ELISA analysis
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[PMID: 36450214] |
In Vitro
Anti-inflammatory agent 33 (compound 8j) (10, 5, 2.5, 1.25, 0.675 μM; 1+24 h) significantly inhibits NO production with the inhibition rate of 93.97% and the IC50 value of 1.25 µM in LPS-induced RAW264.7 cells[1].
Anti-inflammatory agent 33 (1.25, 2.5, 5, 10, 20 µM; 1+24 h) inhibits the production of TNF-α and IL-1β with IC50 values of 11.5, 8.48 μM, respectively[1].
Anti-inflammatory agent 33 (1, 3, 5 µM; 1+24 h) inhibits LPS-induced iNOS, COX-2, p-p38α; p-MK2 protein expression in a dose-dependent manner in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:1, 3, 5 µM
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Incubation Time:1+24 h
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Result:Inhibited the LPS-induced expression of pro-inflammatory mediators iNOS, COX-2, p-p38α; p-MK2 in the RAW264.7 cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:160-180 g, female Sprague–Dawley rats (AIA model)[1]
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Dosage:10, 30 mg/kg
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Administration:Once a day for 14 days
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Result:Significantly reduced the swelling of the feet of the rats in a dose-dependent manner.
Chemical Information
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CAS No. 2816993-09-4
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Masse moléculaire 433.44
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Formule C22H15N3O5S
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SMILES
COC1=CC=C(C=C1)S(=O)(NC2=CC3=C(N=C4C(C5=CC=CC=C5N4C3=O)=O)C=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 33 Related Classifications
HY-151921 Related Classifications
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