1. Anti-infection
    Apoptosis
    Stem Cell/Wnt
    JAK/STAT Signaling
    Cell Cycle/DNA Damage
    MAPK/ERK Pathway
    Protein Tyrosine Kinase/RTK
    NF-κB
  2. Parasite
    Apoptosis
    STAT
    Topoisomerase
    ERK
    FAK
    p38 MAPK
    NF-κB
  3. Nitidine chloride

Nitidine chloride 

Cat. No.: HY-N0498 Purity: 99.26%
Handling Instructions

Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway.

For research use only. We do not sell to patients.

Nitidine chloride Chemical Structure

Nitidine chloride Chemical Structure

CAS No. : 13063-04-2

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
20 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5][6].

Molecular Weight

383.82

Formula

C₂₁H₁₈ClNO₄

CAS No.

13063-04-2

SMILES

C[N+]1=CC2=CC(OC)=C(OC)C=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*Nitidine chloride is usually formulated as a suspension.

References
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Keywords:

NitidineParasiteApoptosisSTATTopoisomeraseERKFAKp38 MAPKNF-κBExtracellular signal regulated kinasesPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Nitidine chloride
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HY-N0498
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