1. Apoptosis
    Stem Cell/Wnt
    JAK/STAT Signaling
    Cell Cycle/DNA Damage
    MAPK/ERK Pathway
    Protein Tyrosine Kinase/RTK
    NF-κB
  2. Apoptosis
    STAT
    Topoisomerase
    ERK
    FAK
    p38 MAPK
    NF-κB
  3. Nitidine chloride

Nitidine chloride 

Cat. No.: HY-N0498
Handling Instructions

Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway.

For research use only. We do not sell to patients.

Nitidine chloride Chemical Structure

Nitidine chloride Chemical Structure

CAS No. : 13063-04-2

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Description

Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5][6].

Molecular Weight

383.82

Formula

C₂₁H₁₈ClNO₄

CAS No.

13063-04-2

SMILES

C[N+]1=CC2=CC(OC)=C(OC)C=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5.[Cl-]

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NitidineApoptosisSTATTopoisomeraseERKFAKp38 MAPKNF-κBExtracellular signal regulated kinasesPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Nitidine chloride
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